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Abstract Coronal holes are the observational manifestation of the solar magnetic field open to the heliosphere and are of pivotal importance for our understanding of the origin and acceleration of the solar wind. Observations from space missions such as the Solar Dynamics Observatory now allow us to study coronal holes in unprecedented detail. Instrumental effects and other factors, however, pose a challenge to automatically detect coronal holes in solar imagery. The science community addresses these challenges with different detection schemes. Until now, little attention has been paid to assessing the disagreement between these schemes. In this COSPAR ISWAT initiative, we present a comparison of nine automated detection schemes widely applied in solar and space science. We study, specifically, a prevailing coronal hole observed by the Atmospheric Imaging Assembly instrument on 2018 May 30. Our results indicate that the choice of detection scheme has a significant effect on the location of the coronal hole boundary. Physical properties in coronal holes such as the area, mean intensity, and mean magnetic field strength vary by a factor of up to 4.5 between the maximum and minimum values. We conclude that our findings are relevant for coronal hole research from the past decade, and are therefore of interest to the solar and space research community.
Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles or other approaches for vision correction. Common genetic risk factors have been identified by genome-wide association studies (GWAS), but a great part of the refractive error heritability is still missing. Some of this heritability may be explained by rare variants (minor allele frequency [MAF] ≤ 0.01.). We performed multiple gene-based association tests of mean Spherical Equivalent with rare variants in exome array data from the Consortium for Refractive Error and Myopia (CREAM). The dataset consisted of over 27,000 total subjects from five cohorts of Indo-European and Eastern Asian ethnicity. We identified 129 unique genes associated with refractive error, many of which were replicated in multiple cohorts. Our best novel candidates included the retina expressed PDCD6IP, the circadian rhythm gene PER3, and P4HTM, which affects eye morphology. Future work will include functional studies and validation. Identification of genes contributing to refractive error and future understanding of their function may lead to better treatment and prevention of refractive errors, which themselves are important risk factors for various blinding conditions.
Refractive errors, including myopia, are the most frequent eye disorders worldwide and an increasingly common cause of blindness. This genome-wide association meta-analysis in 160,420 participants and replication in 95,505 participants increased the number of established independent signals from 37 to 161 and showed high genetic correlation between Europeans and Asians (>0.78). Expression experiments and comprehensive in silico analyses identified retinal cell physiology and light processing as prominent mechanisms, and also identified functional contributions to refractive-error development in all cell types of the neurosensory retina, retinal pigment epithelium, vascular endothelium and extracellular matrix. Newly identified genes implicate novel mechanisms such as rod-and-cone bipolar synaptic neurotransmission, anterior-segment morphology and angiogenesis. Thirty-one loci resided in or near regions transcribing small RNAs, thus suggesting a role for post-transcriptional regulation. Our results support the notion that refractive errors are caused by a light-dependent retina-to-sclera signaling cascade and delineate potential pathobiological molecular drivers.