Kaikki aineistot
Lisää
Abstract The ingenious concept of phase reversion annealing involving cold deformation of parent austenite to strain-induced martensite, followed by annealing was used to obtain nano-grained/ultrafine-grained (NG/UFG) structure in a Cu-bearing biomedical austenitic stainless steel resulting in high strength-high ductility combination. Having employed the concept effectively, the primary objective of this study is to critically analyze the interplay between the load-controlled deformation response, strain-rate sensitivity and deformation mechanism of NG/UFG austenitic stainless steel via nanoscale deformation experiments and compare with its coarse-grained (CG) counterpart. The study demonstrated that the strain-rate sensitivity of NG/UFG was ~1.5 times that of the CG structure. Post-mortem electron microscopy of plastic zone surrounding the indents indicated that the active deformation mechanism was nanoscale twinning with typical characteristics of a network of intersecting twins in the NG/UFG structure, while strain-induced martensite transformation was the effective deformation mechanism for the CG structure. The fracture morphology was also different for the two steels, essentially ductile in nature, and was characterized by striations marking the line-up of voids in NG/UFG steel and microvoid coalescence in CG counterpart. The differences in deformation mechanisms between the NG/UFG and CG structure are attributed to the austenite stability — strain energy relationship. Furthermore, the presence of ~3 wt % Cu in austenitic stainless steel had somewhat moderate effect on strain-rate sensitivity and activation volume at similar level of grain size in its Cu-free counterpart. Specifically, in the NG/UFG structure, the nanoscale twin density was noticeably higher in Cu-bearing austenitic stainless steel as compared to Cu-free counterpart, as Cu is known to increase the stacking fault energy.
Abstract New Product Development (NPD) is vital for companies that operate in international markets. Yet, NPD has become increasingly challenging to manage; products are becoming ever more complex and various customers and multiple stakeholders’ needs must be satisfied. Additionally, NPD is often conducted in multiple locations around the world. Product development drivers can be defined as reasons for a company to initiate a product development project. These drivers affect decision-making, project outcome, and product strategy implementation. This study explores how product development drivers are perceived at the managerial level in technology companies based in Finland and China. The results indicate that managers’ views on these drivers differ in short-, medium-, and long-term development projects. Marketing and customers related drivers are considered the most important in the short term; financial goals related drivers in the medium term, and strategy and business environment related drivers in the long term. Furthermore, differences are found between Finnish and Chinese managers’ views. Finnish practitioners tend to be more focused on financial goals related drivers, whereas Chinese managers consider various factors important.
Fast-camera observations of distinctive forked patterns caused by disintegrating molten metal particles in the JET tokamak are presented. These patterns are characterised by repeated splitting of particles into pairs of equally sized sub-particles; such regularity can only be explained by the two-lobed bifurcations of liquid droplets rotating with velocities in excess of 105s-1. These speeds are consistent with longstanding theories of particle spin-up in magnetized plasmas but are at least two orders of magnitude greater than any previous measurement of rotating particles in plasmas. The verification of spontaneous liquid particle spinning processes in plasmas has widespread implications in astrophysics, particularly for the explanation of anomalous microwave radiation and its associated measurements of the cosmic magnetic field. Furthermore, by incorporating the rotation of droplets into the dust tracking code DTOKS, the fast-camera observations are reliably replicated in JET and predictions for future droplet behaviour in next-generation tokamaks can be made. These simulations show that the higher magnetic fields, plasma temperatures and densities of ITER will enhance the breakup process, thus protecting the core plasma from acute impurity deposition and subsequent disruption events and providing significant operational benefits.
Abstract Multi‐instrument observations by a meteor radar (MR), auroral cameras, ionosondes, and ground magnetometers were made in Northern Europe at auroral latitudes (between 64° and 72° corrected geomagnetic latitude) at 22–24 magnetic local time in the substorm growth phase. The southward drifting growth phase auroral arc was associated with enhanced electron density up to 2⋅1012 m‐3 (corresponding to a plasma frequency, foEs of about 13 MHz) at about 110‐km altitude. Such an enhanced E layer electron density caused bending toward the ground of the MR radio waves transmitted at a frequency, fr, of 36.9 MHz and at low elevation (el. < 25°), such that the radar received ground echoes characterized by a near‐zero Doppler shift. The amplitude of the echoes was modulated at a frequency of a few hertz, and a similar modulation was found in the auroral luminosity at 427.8 nm near the location of the bending of MR radio waves. The modulation was due to irregular (random) fluctuations of auroral precipitation. Although such a few‐hertz variation of the auroral precipitation cannot produce more than 1% modulation of the ionospheric electron density, even such a small modulation can lead to 50% modulation of the MR ground scatter provided foEs ≈ fr sin (el.). The ionosonde and MR data provide evidence that this condition was satisfied in the present case. Due to a high‐frequency (>2 Hz) amplitude modulation of the ground scatter, the MR erroneously accepts such signals as echoes from meteor trails.
Abstract Two types of core–shell heterostructure TiO2 nanofibers (noted as core@shell TiO2 NFs) were synthesized by sequential hydrothermal, calcination, and impregnation processes. Rutile TiO2 nanofibers (R TiO2 NFs) core with anatase TiO2 nanoparticles (A TiO2 NPs) shell is denoted as R@A TiO2 NFs, and the reverse structure with anatase TiO2 NFs core (A TiO2 NFs) and rutile TiO2 nanoparticles shell (R TiO2 NPs) is denoted as A@R TiO2 NFs. In our study, the photodegradation of organic dyes and Kelvin probe force microscopy (KPFM) analysis were applied to shed light on the mechanism of the excited electron–hole pair separation. The results of photodegradation showed that the A@R TiO2 NFs have the highest activity under UV-B and UV-A irradiation, being nearly 3-fold higher as compared to AEROXIDE TiO2 P25. The results in conjunction with KPFM measurements indicated that, in the heterostructure, electron–hole pairs are efficiently separated, the excited electrons stay in the anatase phase, and holes are injected to the rutile phase. When the A@R TiO2 NFs heterostructures are decorated with Pt nanoparticles (Pt-A@R TiO2 NFs), the nanocomposite is particularly active in photocatalytic hydrogen evolution from ethanol–water mixtures with a production rate of ∼8,500 μmol/h·g. Our study not only explains the role of anatase–rutile junctions in photocarrier separation, but also projects the development of other efficient photocatalytic heterostructures for green energy production and conversion.
Abstract Background/Objectives: Until now, there have been many studies on the postoperative stability of orthognathic patients treated with traditional fixed orthodontic appliances. Recently, the use of clear aligners as orthodontic appliances has increased in orthodontic treatment for aesthetic and patient convenience. The aim of this preliminary study was to investigate the stability and characteristics of patients undergoing orthognathic surgery using clear aligners. Patients and methods: This study was performed on patients who underwent orthognathic surgery by one surgeon at Pusan National University Dental Hospital from April 2017 to August 2021. A comparative study was conducted on five patients treated with clear aligners during orthodontic treatment and ten patients treated with traditional fixed appliances as a control group. Postoperative skeletal changes and recurrence were evaluated by cone beam computed tomography and lateral cephalometric radiographs taken two days postoperatively and six months postoperatively. Several measurement variables were used to confirm the presence or absence of recurrence, preoperative and postoperative orthodontic treatment period, and the number of extracted teeth. Results: Postoperative stability for six months after surgery was not significantly different between the clear aligner group and the traditional fixed appliance group. The preoperative orthodontic treatment period was also shorter in the clear aligner group, and the number of extracted premolar teeth and impacted teeth were also fewer in the clear aligner group, but there was no significant difference. Conclusions: Orthodontic treatment using clear aligners continues to develop, and it is believed that there is no limit to what can be accomplished during orthodontic surgery accompanied by clear aligners.
We present high-resolution electron energy-loss data and theoretical modeling for the vibrational properties of an atomic monolayer of H (D) on the Pt(111) surface. Experimentally we find three loss peaks, in contrast with two peaks visible in the low-coverage case. A three-dimensional adiabatic potential-energy surface at full coverage of hydrogen is obtained through first-principles calculations. When the zero-point energy effects are included, the minimum energy adsorption site is found to be the fcc site just as in the low-coverage case. Vibrational band states for motion in this potential-energy surface are computed and the excited states associated with the observed loss peaks identified.
We present a combination of theoretical calculations and experiments for the low-lying vibrational excitations of H and D atoms adsorbed on the Pt(111) surface. The vibrational band states are calculated based on the full three-dimensional adiabatic potential energy surface obtained from first-principles calculations. For coverages less than three quarters of a monolayer, the observed experimental high-resolution electron peaks at 31 and 68 meV are in excellent agreement with the theoretical transitions between selected bands. Our results convincingly demonstrate the need to go beyond the local harmonic oscillator picture to understand the dynamics of this system.
Abstract We describe here the relationship between grain structure, deformation mechanism and fracture characteristics in an austenitic stainless steel. This was accomplished using the novel concept of phase reversion that enabled a wide range of grain size from nanograined/ultrafine grained (NG/UFG) to coarse-grained (CG) regime to be obtained in a single material through change in temperature-time annealing sequence. In the NG/UFG structure, a marked increase in abundance of stacking faults (SFs) and twin density with strain was observed that led to a decrease in the average spacing between adjacent SFs, thus converting stacking faults into twins. Twinning in NG/UFG structure involved partial dislocations and their interaction with the grain boundaries, including SF overlapping and the coordinated nucleation of partial dislocations from the grain boundaries. The plastic zone in the NG/UFG structure resembled a network knitted by the intersecting twins and SFs. With SFE ~30 mJ/m2, the minimum stress for twin nucleation was ~250 MPa for the experiment steel and the corresponding optimal grain size (dop) wa ~120 nm. In contrast, in the CG structure, strain induced martensite formation was the deformation mechanism. The difference in the deformation mechanism led to a clear distinction in the fracture behavior from striated fracture in high strength-high ductility NG/UFG alloy to microvoid coalescence in the low strength-high ductility CG counterpart. The underlying reason for the change in fracture behavior was consistent with change in deformation mechanism from nanoscale twinning in NG/UFG alloy to strain-induced martensite in the CG alloy, which is related to change in the stability of austenite with grain size. An analysis of critical shear stress required to initiate twinning partial dislocations in comparison to that required to nucleate shear bands is presented. The appearance of striated fracture in the NG/UFG alloy suggests a quasi-static step wise crack growth process.
Abstract Background: The aim of this study was to assess the associations of modifiable lifestyle factors (smoking, coffee consumption, sleep, and physical activity) and cardiometabolic factors (body mass index, glycemic traits, type 2 diabetes, systolic and diastolic blood pressure, lipids, and inflammation and kidney function markers) with risks of any (ruptured or unruptured) intracranial aneurysm and aneurysmal subarachnoid hemorrhage using Mendelian randomization. Methods and Results: Summary statistical data for the genetic associations with the modifiable risk factors and the outcomes were obtained from meta‐analyses of genome‐wide association studies. The inverse‐variance weighted method was used as the main Mendelian randomization analysis, with additional sensitivity analyses conducted using methods more robust to horizontal pleiotropy. Genetic predisposition to smoking, insomnia, and higher blood pressure was associated with an increased risk of both intracranial aneurysm and aneurysmal subarachnoid hemorrhage. For intracranial aneurysm, the odds ratios were 3.20 (95% CI, 1.93–5.29) per SD increase in smoking index, 1.24 (95% CI, 1.10–1.40) per unit increase in log‐odds of insomnia, and 2.92 (95% CI, 2.49–3.43) per 10 mm Hg increase in diastolic blood pressure. In addition, there was weak evidence for associations of genetically predicted decreased physical activity, higher triglyceride levels, higher body mass index, and lower low‐density lipoprotein cholesterol levels with higher risk of intracranial aneurysm and aneurysmal subarachnoid hemorrhage, with 95% CI overlapping the null for at least 1 of the outcomes. All results were consistent in sensitivity analyses. Conclusions: This Mendelian randomization study suggests that smoking, insomnia, and high blood pressure are major risk factors for intracranial aneurysm and aneurysmal subarachnoid hemorrhage.
Abstract New Product Development (NPD) is vital for companies that operate in international markets. Yet, NPD has become increasingly challenging to manage; products are becoming ever more complex and various customers and multiple stakeholders’ needs must be satisfied. In addition, international companies often conduct NPD in multiple locations around the world. Product development drivers can be defined as reasons for a company to initiate a product development project. These drivers affect decision-making, project outcome, and product strategy implementation. The purpose of this paper is to study how key product development drivers are perceived at the managerial level in product innovation focused technology companies that are based in Finland and China. The study is exploratory in nature. Previous studies have not adequately explored drivers for different types of development and countryspecific characteristics. The results of this study indicate that managers’ views on the product development drivers differ in short-, medium-, and long-term development projects. Marketing and customers related drivers are considered the most important in the short term, financial goals related drivers in the medium term, and strategy and business environment related drivers in the long term. In addition, differences are found between Finnish and Chinese managers’ views. Finnish practitioners tend to be more focused on financial goals related drivers, whereas Chinese managers consider various factors to be important. The study provides interesting insights for international companies that want to enhance their product development operations. In addition, future research topics related to product development drivers are proposed.
Abstract The replacement of an unrestorable tooth with a single implant-supported prosthesis is a treatment with predictable and successful outcomes. The anterior maxilla region is a complicated site for such treatment, due to its esthetic, functional, and physiological sensitivity. The purpose of this study was to evaluate the changes in the soft tissue following an immediate implant procedure using guided surgery in combination with a computer-aided design and computer-aided manufacturing (CAD/CAM) customized titanium anatomic abutment in the esthetic zone. A total of 13 patients who had been treated with an immediate post-extraction implant placement and an immediate provisional restoration were included in the study. The changes in the soft tissue dimension, interdental papilla, and esthetic score were evaluated with a follow-up of at least one year. There was no significant change in the midfacial mucosal status when compared to the pre-treatment situation. The recession of the mesial papillary height was 0.32 mm and the distal papillary height was 0.10 mm. The mean horizontal change in the labial mucosa was 0.32 ± 0.83 mm. There was no significant difference between the mesial papilla index and the distal papilla index. The pink esthetic score value prior to treatment was 11.16, and at one-year follow-up, 10.25. Within the limitations of this study, the immediate post-extraction implant placement procedure with a stereolithographic guide and a provisionalization with a CAD/CAM customized titanium anatomic abutment may be a treatment option with predictable outcomes for the replacement of teeth in the esthetic zone.
The current study aimed to predict secondary school students' motivation toward sport injury prevention in 'in-school' and 'out-of-school' contexts, and their sport injury prevention behaviour at 3-month follow-up using the trans-contextual model (TCM). Hong Kong secondary school students (N = 1,566; mean age = 13.34 years, range = 11 to 19; female = 49.42%) were recruited. Participants were asked to complete a survey comprising previously-validated scales measuring TCM constructs at baseline, and a measure of sport injury prevention behaviour at follow-up three months later. Structural equation modeling (SEM) was used to examine the hypothesised paths among TCM constructs. A SEM specifying hypothesised paths among TCM variables showed acceptable fit with the data (χ2 (29) = 418.55, CFI = .93, TLI = .90, and RMSEA = .09, 90% CI [.09, .10], and SRMR = .05). Findings supported tenets of the TCM: the effects of perceived autonomy support from PE teachers on in-school autonomous motivation toward injury prevention, the trans-contextual relationship between students' 'in-school' and 'out-of-school' autonomous motivation toward injury prevention, and the effects of autonomous motivation toward injury prevention on social cognitive variables and subsequent sport injury prevention behaviours. Results supported the tenets proposed within the TCM in predicting students' 'in-school' and 'out-of-school' autonomous motivation toward sport injury prevention. Findings underscore the potential importance of autonomy support from PE teachers in facilitating students' sport injury prevention behaviours. Further longitudinal and intervention research is warranted to establish temporal and causal effects of TCM variables in sport injury prevention.
The current study tested the effects of an intervention based on the trans-contextual model (TCM) on secondary school PE students’ sport injury prevention behaviour, and on theory-based motivational and social cognition mediators. Participants were PE students (N=1,168; Mage=13.322±1.045, range=12 to 16; female=51.721%) who participated in a 3-month cluster-randomised controlled trial. Schools were randomly assigned to a treatment group, in which PE teachers received training to be more supportive of psychological needs in teaching sport injury prevention, or a control group, in which PE teachers received no training. Participants completed survey measures of TCM variables and self-reported sport injury prevention behaviour at baseline and at 3-month post-intervention follow-up. The proposed TCM model exhibited adequate fit with the data, χ2=143.080 (df=19), CFI=.956, TLI=.916, RMSEA=.078 [90% CI=.066 to .090], and SRMR=.058. We found positive, statistically significant direct intervention effects on changes in perceived psychological need support (β=.064, p=.020). We also found positive, significant direct (β=.086 to .599, p<.001) and indirect (β=.002 to .027, p=.020 to .032) intervention effects on changes in TCM variables and behaviours to prevent sport injuries. Our findings support the TCM as a useful framework for building an intervention for promoting sport injury prevention behaviours among secondary school students.
Abstract We report the properties of the ionospheric exit point and characteristics of several types of very low frequency waves, including chorus and quasiperiodic emissions, based on a comprehensive dataset of simultaneous observations between ground and space. Whistler‐mode waves were observed at Kannuslehto (L = 5.5, KAN), Finland, and in the inner magnetosphere by the Japanese Arase satellite. During the 2017–2018 winter campaign, we found 13 cases showing one‐to‐one correspondence of wave spectra between KAN and Arase. This is the first time that such a large number of conjugated events have been reported at once. The duration of the events ranged from a few minutes up to 3 h, with 90% of events detected in the afternoon sector. While the occurrence rate is higher during daytime, this can also be related to a majority of the detected waves being quasiperiodic emissions, a known dayside phenomenon. Arase was usually located within 30° of the equator, at L ∼4–5, and detected mostly waves propagating at oblique angles (≥20°). Frequently, the ionospheric magnetic footprint of Arase was located equatorwards (south) from KAN, often in the same geographical area. We investigated the probable location of the ionospheric exit point of the waves from the location of the footprint of Arase and the angle of arrival of waves detected at KAN. Using density measurements at Arase we discuss magnetospheric wave propagation; we find that, in most cases, waves were unducted in their propagation from the satellite to the ground.
Abstract This paper introduces a new system that can monitor aurora and atmospheric airglow using a low-cost Watec monochromatic imager (WMI) equipped with a sensitive camera, a filter with high transmittance, and the non-telecentric optics. The WMI system with 486-nm, 558-nm, and 630-nm band-pass filters has observable luminosity of about ~200–4000 Rayleigh for 1.07-sec exposure time and about ~40–1200 Rayleigh for 4.27-sec exposure time, for example. It is demonstrated that the WMI system is capable of detecting 428-nm auroral intensities properly, through comparison with those measured with a collocated electron-multiplying charge-coupled device (EMCCD) imager system with narrower band-pass filter. The WMI system has two distinct advantages over the existing system: One makes it possible to reduce overall costs, and the other is that it enables the continuous observation even under twilight and moonlight conditions. Since 2013 a set of multi-wavelength WMIs has been operating in northern Scandinavia, Svalbard, and Antarctica to study meso- and large-scale aurora and airglow phenomena. Future development of the low-cost WMI system is expected to provide a great opportunity for constructing a global network for multi-wavelength aurora and airglow monitoring.
Abstract Rapid (<1 s) intensity modulation of pulsating auroras is caused by successive chorus elements as a response to wave‐particle interactions in the magnetosphere. Here we found that a pulsating auroral patch responds to the time spacing for successive chorus elements and possibly to chorus subpacket structures with a time scale of tens of milliseconds. These responses were identified from coordinated Arase satellite and ground (Gakona, Alaska) observations with a high‐speed auroral imager (100 Hz). The temporal variations of auroral intensity in a few‐hertz frequency range exhibited a spatial concentration at the lower‐latitude edge of the auroral patch. The spatial evolution of the auroral patch showed repeated expansion/contraction with tens of kilometer scales in the ionosphere, which could be spatial behaviors in the wave‐particle interactions. These observations indicate that chorus elements evolve coherently within the auroral patch, which is approximately 900 km in the radial and longitudinal directions at the magnetic equator.
Abstract A physical mechanism to produce pulsating aurora (PsA) has been considered to be the interaction of the electron and the chorus wave generated near the equatorial plane of the magnetosphere. A recent observation of high temporal resolution of chorus waves by the Arase satellite revealed that the presence or absence of the internal modulation of PsA, which is a characteristic sub-second scintillation at 3 ± 1 Hz within each optical pulsation, is closely related to the discreteness of the element structure of the chorus wave. However, it is still unclear what parameters (or conditions) control the discreteness of the element and the existence of the internal modulation of PsA. In this study, we discuss parameters that determine the presence or absence of the internal modulation of PsA and element structure of chorus by showing a conjugate observation of PsA/chorus by ground-based cameras and the Arase satellite. During the event, the occurrence of internal modulation increased temporally. The wave data from the satellite show that the repetitive frequency of elements was ∼6 Hz when the internal modulation was indistinct, while the repetitive frequency was ∼3 Hz when the internal modulation was distinct. The particle measurements suggest that this difference was caused by changes in the density and the temperature anisotropy of the hot electron. The internal modulation was clearly observed when the density of hot electrons decreased and the temperature anisotropy relaxed after the injection. Observations of internal modulations from the ground might allow us to estimate the parameters such as energetic electron density and temperature anisotropy in the magnetosphere.
Abstract This paper focuses on the semi-supervised object detection (SSOD) which makes good use of unlabeled data to boost performance. We face the following obstacles when adapting the knowledge distillation (KD) framework in SSOD. (1) The teacher model serves a dual role as a teacher and a student, such that the teacher predictions on unlabeled images may limit the upper bound of the student. (2) The data imbalance issue caused by the large quantity of consistent predictions between the teacher and student hinders an efficient knowledge transfer between them. To mitigate these issues, we propose a novel SSOD model called Temporal Self-Ensembling Teacher (TSET). Our teacher model ensembles its temporal predictions for unlabeled images under stochastic perturbations. Then, our teacher model ensembles its model weights with those of the student model by an exponential moving average. These ensembling strategies ensure data and model diversity, and lead to better teacher predictions for unlabeled images. In addition, we adapt the focal loss to formulate the consistency loss for handling the data imbalance issue. Together with a thresholding method, the focal loss automatically reweights the inconsistent predictions, which preserves the knowledge for difficult objects to detect in the unlabeled images. The mAP of our model reaches 80.73% and 40.52% on the VOC2007 test set and the COCO2014 minival5k set, respectively, and outperforms a strong fully supervised detector by 2.37% and 1.49%, respectively. Furthermore, the mAP of our model (80.73%) sets a new state-of-the-art performance in SSOD on the VOC2007 test set.
Doping attitude is an individual’s subjective evaluation (e.g., good or bad, useful or useless) toward the use of prohibited performance-enhancing substances or methods in sports. Research on doping attitude has traditionally relied on self-report questionnaire methods to measure the construct (Ntoumanis et al., 2014; Chan et al., 2015). However, as doping in sport is illegal (World AntiDoping Agency, 2015) and perceived as socially unacceptable, athletes who hold positive attitudes toward doping are less likely to reveal them to others. As a result explicit measures of doping attitude are susceptible to potential bias as athletes may respond in a socially desirable fashion (Petróczi and Aidman, 2009; Gucciardi et al., 2010). To counter such bias, implicit measures such as the implicit association test (IAT; Greenwald et al., 1998) have been developed to capture individuals’ non-conscious attitudes toward doping (Brand et al., 2014a,b; Schindler et al., 2015). The current paper aims to introduce a paper-and-pen IAT which could potentially serve as alternative method to the traditional computer-IAT for measuring athletes’ doping attitude.
Abstract The interatomic Auger effect following O 1s ionization in N2O has been experimentally investigated using multi-electron coincidence spectroscopy. The expected transition energies have been established by comparison to the measured N 1s−1v−1 core-valence double ionization energies. We describe a procedure to eliminate the background of two competing processes contributing spectroscopic signatures to the same energy range, namely double Auger decay of the O 1s vacancy and direct single-photon double ionization into the N 1s−1v−1 states. While the interatomic Auger transitions could not be successfully isolated, we provide an upper boundary of the transition probability of 0.07% with respect to the dominant single Auger decay after O 1s ionization.
Abstract Background: We hypothesised that occupational exposures differently affect subtypes of adult-onset asthma. Objective: We investigated potential relations between occupation and three subtypes of adult asthma, namely atopic asthma, non-atopic asthma and asthma–COPD overlap syndrome (ACOS). Methods: This is a population-based case–control study of incident asthma among working-age adults living in Pirkanmaa Hospital District in Southern Finland. The determinant of interest was occupation at the time of diagnosis of asthma or the job that the subject had quit due to respiratory symptoms. Asthma was divided into three mutually exclusive subtypes on the basis of any positive IgE antibody (atopic and non-atopic asthma) and presence of persistent airways obstruction in spirometry (ACOS). We applied unconditional logistic regression analysis to estimate adjusted OR (aOR), taking into account gender, age and smoking. Results: The following occupational groups showed significantly increased risk of atopic asthma: chemical industry workers (aOR 15.76, 95% CI 2.64 to 94.12), bakers and food processors (aOR 4.69, 95% CI 1.18 to 18.69), waiters (aOR 4.67, 95% CI 1.40 to 15.56) and those unemployed (aOR 3.06, 95% CI 1.52 to 6.17). The following occupations showed clearly increased risk of non-atopic asthma: metal workers (aOR 8.37, 95% CI 3.77 to 18.59) and farmers and other agricultural workers (aOR 2.36, 95% CI 1.10 to 5.06). Some occupational groups showed statistically significantly increased OR of ACOS: electrical and electronic production workers (aOR 30.6, 95% CI 6.10 to 153.35), fur and leather workers (aOR 16.41, 95% CI 1.25 to 215.85) and those retired (aOR 5.55, 95% CI 1.63 to 18.97). Conclusions: Our results show that different occupations are associated with different subtypes of adult-onset asthma.
Abstract Purpose: Modic changes (MC) on magnetic resonance imaging (MRI) have been associated with the development and severity of low back pain (LBP). The etiology of MC remains elusive, but it has been suggested that altered metabolism may be a risk factor. As such, this study aimed to identify metabolomic biomarkers for MC phenotypes of the lumbar spine via a combined metabolomic-genomic approach. Methods: A population cohort of 3,584 southern Chinese underwent lumbar spine MRI. Blood samples were genotyped with single-nucleotide polymorphisms (SNP) arrays (n = 2,482) and serum metabolomics profiling using magnetic resonance spectroscopy (n = 757), covering 130 metabolites representing three molecular windows, were assessed. Genome-wide association studies (GWAS) were performed on each metabolite, to construct polygenic scores for predicting metabolite levels in subjects who had GWAS but not metabolomic data. Associations between predicted metabolite levels and MC phenotypes were assessed using linear/logistic regression and least absolute shrinkage and selection operator (LASSO). Two-sample Mendelian randomization analysis tested for causal relationships between metabolic biomarkers and MC. Results: 20.4% had MC (10.6% type 1, 67.2% type 2, 22.2% mixed types). Significant MC metabolomic biomarkers were mean diameter of very-low-density lipoprotein (VLDL)/low-density lipoprotein (LDL) particles and cholesterol esters/phospholipids in large LDL. Mendelian randomization indicated that decreased VLDL mean diameter may lead to MC. Conclusions: This large-scale study is the first to address metabolomics in subject with/without lumbar MC. Causality studies implicate VLDL related to MC, noting a metabolic etiology. Our study substantiates the field of “spino-metabolomics” and illustrates the power of integrating metabolomics-genomics-imaging phenotypes to discover biomarkers for spinal disorders, paving the way for more personalized spine care for patients.
The present study fabricates biogenic zinc oxide nanoparticles (ZnO NPs) with the aqueous leaf extract of Annona muricata (Am) plant collected from semi-evergreen forests of Odisha, India. The synthesized Am-ZnO NPs were physicochemically characterized. The ultraviolet/visible spectrum showed the maximum optical absorbance of Am-ZnO NPs at 355 nm. High-resolution transmission electron microscopy analysis presented the nearly spherical shape of Am-ZnO NPs with an average particle size of 80 nm. The net surface charge and hydrodynamic size of Am-ZnO NPs were measured to be ∼−2.59 mV and ∼417 nm, respectively. Am-ZnO NPs were found to be biocompatible and hemocompatible nature. Furthermore, Am-ZnO NPs displayed strong anticancer effects on both 2D and 3D tumor models. We observed a dose-dependent toxicity on both A549 and MOLT4 cells and observed a size reduction in the A549 tumor spheroids. Subsequently, we observed a depolarization in mitochondrial membrane potential of Am-ZnO NP–treated cancer cells leading to the apoptosis induction in cancer cells.
We present results from a parsec-scale jet kinematics study of 409 bright radio-loud active galactic nuclei (AGNs) based on 15 GHz Very Long Baseline Array (VLBA) data obtained between 1994 August 31 and 2016 December 26 as part of the 2 cm VLBA survey and Monitoring Of Jets in Active galactic nuclei with VLBA Experiments (MOJAVE) programs. We tracked 1744 individual bright features in 382 jets over at least 5 epochs. A majority (59%) of the best-sampled jet features showed evidence of accelerated motion at the >3σ level. Although most features within a jet typically have speeds within ∼40% of a characteristic median value, we identified 55 features in 42 jets that had unusually slow pattern speeds, nearly all of which lie within 4 pc (100 pc deprojected) of the core feature. Our results, combined with other speeds from the literature, indicate a strong correlation between apparent jet speed and synchrotron peak frequency, with the highest jet speeds being found only in low-peaked AGNs. Using Monte Carlo simulations, we find best-fit parent population parameters for a complete sample of 174 quasars above 1.5 Jy at 15 GHz. Acceptable fits are found with a jet population that has a simple unbeamed power-law luminosity function incorporating pure luminosity evolution and a power-law Lorentz factor distribution ranging from 1.25 to 50 with slope -1.4 ± 0.2. The parent jets of the brightest radio quasars have a space density of 261 ± 19 Gpc -3 and unbeamed 15 GHz luminosities above ∼10 24.5 W Hz -1 , consistent with FR II class radio galaxies.
Abstract Aims: Previous studies have demonstrated that the tumour–stroma ratio (TSR) and tumour budding are of prognostic value for oral squamous cell carcinomas (OSCCs). The aim of this study was to evaluate the prognostic significance of those histological parameters, individually and in combination, for OSCC. Methods and results: The TSR and tumour budding (the presence of five or more buds at the invasive front) were estimated in 254 patients with OSCC. The clinicopathological association was investigated with a chi‐square test, and the prognostic significance (cancer‐specific survival and disease‐free survival) was verified with Kaplan–Meier analysis and the Cox proportional hazard model. The TSR (≥50%, stroma‐rich) was significantly and independently associated with both shortened cancer‐specific survival and poor disease‐free survival, whereas tumour budding was significantly associated with reduced cancer‐specific survival. The TSR/tumour budding model was independently associated with a high risk of cancer mortality and recurrence (disease‐free survival). In patients with early‐stage tumours (clinical stage I and II, n = 103), the TSR, tumour budding and the TSR/tumour budding model were significantly associated with both cancer‐related death and recurrence, whereas, in advanced‐stage tumours (clinical stage III and IV, n = 144), only the TSR and the TSR/tumour budding model were significantly associated with cancer‐specific survival. Conclusion: The TSR, tumour budding and their combination provide significant information on OSCC outcome, suggesting that their incorporation in the routine evaluation of histopathological specimens might be useful in prognostication for OSCC patients.
The 28 GHz Ion Source VENUS (versatile ECR for nuclear science) is back in operation after the superconducting sextupole leads were repaired and a fourth cryocooler was added. VENUS serves as an R&D device to explore the limits of electron cyclotron resonance source performance at 28 GHz with its 10 kW gryotron and optimum magnetic fields and as an ion source to increase the capabilities of the 88-Inch Cyclotron both for nuclear physics research and applications. The development and testing of ovens and sputtering techniques cover a wide range of applications. Recent experiments on bismuth demonstrated stable operation at 300 eμA of Bi31+, which is in the intensity range of interest for high performance heavy-ion drivers such as FRIB (Facility for Rare Isotope Beams). In addition, the space radiation effects testing program at the cyclotron relies on the production of a cocktail beam with many species produced simultaneously in the ion source and this can be done with a combination of gases, sputter probes, and an oven. These capabilities are being developed with VENUS by adding a low temperature oven, sputter probes, as well as studying the RF coupling into the source.
Abstract Purpose: This study aimed to measure the amount of change in the mandibular angle, intergonial width, and ramus angulation due to intersegmental interference and changes in condyle position after mandibular bilateral sagittal split ramus osteotomy (BSSRO) in patients with mandibular prognathism and to evaluate the correlation between them. Materials and methods: A total of 32 patients who underwent mandibular setback using the BSSRO of the mandible to manage skeletal prognathism during the years 2018 to 2020 at the Department of Oral and Maxillofacial Surgery, Pusan National University were followed both clinically and with cone beam computed tomography (CBCT) for at least one year. Those who were also treated with genioplasty or other orthognathic surgery were excluded from the study. The mandibular angle (gonial angle: Ar–Go–Me), intergonial width (Go–Go), and total angle (sum of left and right proximal segmental angle) were recorded. Changes in the ramus were compared and analyzed before surgery (T1), immediately after surgery (T2), and one year following surgery (T3). Results: The mandibular angle increased by an average of 0.14 degrees immediately after surgery (T2–T1) and increased by 0.97 degrees at 12 months postoperatively (T3–T2). No correlation was observed with the amount of change in each group relative to the amount of mandibular setback. The mandibular width decreased by 0.01 mm on average immediately after surgery (T2–T1), and by 4.2 mm on average at 12 months after surgery (T3–T2). The angle of the mesial fragment of the mandible increased by 1.04 degrees immediately after surgery (T2–T1), compared to the preoperative state. It decreased by 0.86 degrees at 12 months postoperatively (T3–T2). Conclusion: The increase in the mandibular angle from immediately after surgery to 12 months after BSSRO reflects the counterclockwise rotational tendency to prevent opening restriction when intentionally selecting the condylar position. The decrease in the intergonial width immediately after surgery is thought to be due to the effect of internal trimming to minimize the bone interference between the outer surface of the distal bone fragment and the inner surface of the mesial fragment, and the decrease 1 year after surgery can be considered to be due to bone remodeling. Interosseous interference during mandibular setback osteotomy does not necessarily cause an increase in the width of the mandibular angle after surgery.
Abstract Microbursts are impulsive (<1 s) injections of electrons into the atmosphere, thought to be caused by nonlinear scattering by chorus waves. Although attempts have been made to quantify their contribution to outer belt electron loss, the uncertainty in the overall size and duration of the microburst region is typically large, so that their contribution to outer belt loss is uncertain. We combine datasets that measure chorus waves (Van Allen Probes [RBSP], Arase, ground-based VLF stations) and microburst (>30 keV) precipitation (FIREBIRD II and AC6 CubeSats, POES) to determine the size of the microburst-producing chorus source region beginning on 5 December 2017. We estimate that the long-lasting (∼30 hr) microburst-producing chorus region extends from 4 to 8 ΔMLT and 2–5 ΔL. We conclude that microbursts likely represent a major loss source of outer radiation belt electrons for this event.
Abstract Knee osteoarthritis (OA) is a heterogeneous disease associated with substantial effects on quality of life, and its clinical management is difficult. Among the several available guidelines for the management of knee OA, those from OARSI and ESCEO were updated in 2019. Here, we examine the similarities and differences between these two guidelines and provide a narrative to help guide health-care providers through the complexities of non-surgical management of knee OA. OARSI and ESCEO both recommend education, structured exercise and weight loss as core treatments, topical NSAIDs as first-line treatments and oral NSAIDs and intra-articular injections for persistent pain. Low-dose, short-term acetaminophen, pharmaceutical grade glucosamine and chondroitin sulfate are recommended by ESCEO whereas OARSI strongly recommends against their use (including all glucosamine and chondroitin formulations). Despite this difference, the two guidelines are consistent in the majority of their recommendations and provide useful treatment recommendations for individuals with OA and health-care providers.
Abstract A new and putatively endemic species of Hydroclathrus, Hydroclathrus rapanuii, is described from the geographically isolated Easter Island in the southeastern Pacific based on morphological and molecular phylogenetic data. It is distinguished from other Hydroclathrus by thalli of unevenly furrowed thin membranes, and angular, block-like plurangial sori. Our phylogenetic analyses indicated that H. rapanuii is closely related to the generitype Hydroclathrus clathratus. We also report on the morphology and phylogeny of Chnoospora minima from Easter I. and elsewhere in the Indo-Pacific Ocean, noting the previously unreported presence of hollow portions in its medulla. Although not collected from Easter I., we herein propose the recognition of two new genera, Dactylosiphon gen. nov. and Pseudochnoospora gen. nov., based on our three-gene phylogeny and their known morphologies and anatomies. Dactylosiphon is based on the three species currently assigned to Colpomenia (C. bullosa, C. durvillei, and C. wynnei) that are genetically and morphologically (i.e. thalli with erect and finger-like tubes arising from a common saccate base) distinct from other members of Colpomenia. The monotypic genus Pseudochnoospora is represented by the decumbent, branching, and interadhesive species currently known as Chnoospora implexa. With the above proposals, we further increase the genus-level diversity of Scytosiphonaceae in the Indo-Pacific Ocean.
Abstract Background context: There is often discrepancy between clinical presentation and lumbar magnetic resonance imaging (MRI) findings. Purpose: The purpose of this study was to assess the relationship of high-intensity zones (HIZs) on MRI with low back pain (LBP), sciatica, and back-related disability. Study design: Cross-sectional, population-based Southern Chinese cohort study. Patient sample: Of 1,414 possible participants, data from 1,214 participants (453 males, 761 females; mean age of 48.1±6.3 years) were included. Outcome measures: Presence of single-level, homogeneous multilevel (same type HIZs of morphology and topography) and heterogeneous multilevel (mixed type HIZs of morphology and topography) HIZs and other MRI phenotypes were assessed at each level with T2-weighted 3T sagittal MRI of L1–S1. Associations with LBP, sciatica and Oswestry Disability Index were correlated with HIZ profiles. Results: In all, 718 individuals had HIZs (59.1%). Disc degeneration/displacement were more prevalent in HIZ individuals (p<.001). HIZ subjects experienced prolonged severe LBP more frequently (39.6% vs. 32.5%; p<.05) and had higher Oswestry Disability Index scores (10.7±13.7 vs. 8.9±11.3; p<.05). Posterior multilevel HIZ were significantly associated with prolonged severe LBP (OR: 2.18; 95% CI:1.42–3.37; p<.05) in comparison to anterior only, anterior/posterior or other patterns of HIZ. Multilevel homogeneous or heterogeneous HIZs were significantly associated with prolonged, severe LBP (OR: 1.53–1.57; p<.05). Individuals with homogeneous HIZs had a higher risk of sciatica (OR: 1.51, 95% CI: 1.01–2.27; p<.05). Conclusions: This is the first large-scale study to note that lumbar HIZs, and specific patterns therein, are potentially clinically-relevant imaging biomarkers that are independently and significantly associated with prolonged/severe LBP and sciatica. HIZs, especially homogenous multilevel HIZ, should be noted in the global pain imaging phenotype assessment.
In this work, an original ion-imprinted polymer (IIP) was synthetized for the highly selective removal of Ni(II) ions in neutral and acidic media. First a novel functional monomer (AMP-MMA) was synthetized through the amidation of 2-(aminomethyl)pyridine (AMP) with methacryloylchloride. Following Ni(II)/AMP-MMA complex formation study, the Ni(II)-IIP was produced via inverse suspension polymerization (DMSO in mineral oil) and characterized with solid state 13C CPMAS NMR, FT-IR, SEM and nitrogen adsorption/desorption experiments. The Ni(II)-IIP was then used in solid-phase extraction of Ni(II) exploring a wide range of pH (from neutral to strongly acidic solution), several initial concentrations of Ni(II) (from 0.02 to 1 g/L), and the presence of competitive ions (Co(II), Cu(II), Cd(II), Mn(II), and Mg(II)). The maximum Ni(II) adsorption capacity at pH 2 and pH 7 reached values of 138.9 mg/g and 169.5 mg/g, that are among the best reported in literature. The selectivity coefficients toward Cd(II), Mn(II), Co(II), Mg(II) and Cu(II) are also very high, with values up to 38.6, 32.9, 25.2, 23.1 and 15.0, respectively. The Ni(II)-IIP showed good reusability of up to 5 cycles both with acidic and basic Ni(II) eluents.
Abstract There has been increasing evidence for pitch angle scattering of relativistic electrons by electromagnetic ion cyclotron (EMIC) waves. Theoretical studies have predicted that the loss time scale of MeV electrons by EMIC waves can be very fast, suggesting that MeV electron fluxes rapidly decrease in association with the EMIC wave activity. This study reports on a unique event of MeV electron loss induced by EMIC waves based on Arase, Van Allen Probes, and ground‐based network observations. Arase observed a signature of MeV electron loss by EMIC waves, and the satellite and ground‐based observations constrained spatial‐temporal variations of the EMIC wave activity during the loss event. Multisatellite observation of MeV electron fluxes showed that ~2.5‐MeV electron fluxes substantially decreased within a few tens of minutes where the EMIC waves were present. The present study provides an observational estimate of the loss time scale of MeV electrons by EMIC waves.
Abstract In this study, we aimed to determine if pretreatment low-density lipoprotein (LDL) levels and aortic stenosis (AS) severity alter the efficacy of lipid-lowering therapy on reducing aortic valve replacement (AVR). We used 1,687 patients with asymptomatic mild-to-moderate AS, who were randomly assigned (1:1) to 40/10 mg simvastatin/ezetimibe combination versus. placebo in the simvastatin and ezetimibe in aortic stenosis (SEAS) trial. Pretreatment LDL levels (>4 mmol/L) and peak aortic jet velocity (3 m/s) were used to partition study participants into 4 groups, which were followed for a primary endpoint of AVR. Cox regression with tests for interaction was used to study the effect of randomized treatment in each subgroup. During a median follow-up of 4.3 years (IQR 4.2 to 4.7 years; total 7,396 patient-years of follow-up), 478 (28%) patients underwent AVR and 146 (9%) died. A significant risk dependency was detected between simvastatin/ezetimibe combination, LDL levels and mild versus moderate AS on rates of AVR (p = 0.01 for interaction). In stratified analyses, randomized treatment, therefore, reduced the rate of AVR in patients with LDL levels >4 mmol and mild AS at baseline (HR 0.4; 95% CI: 0.2 to 0.9). There was no detectable effect of randomized treatment on the need for AVR in the 3 other participants subgroups. We conclude, that in a secondary analysis from a prospective randomized clinical trial, treatment with simvastatin/ezetimibe combination reduced the need for AVR in a subset of patients with mild AS and high pretreatment LDL levels (Unique identifier on clinicaltrials.gov: NCT00092677).
Objectives: The aim of this prospective study was to examine the utility of an integrated model comprising constructs from self-determination theory (SDT) and the theory of planned behavior (TPB) in predicting adherence to a post-surgery rehabilitation program in patients receiving anterior cruciate ligament (ACL) reconstruction. Constructs of the integrated model measured at baseline were expected to predict patients' rehabilitation adherence two months later. Method: Patients (N = 121, M age = 27.62, range = 18–53; 36.66% female) scheduled to have ACL reconstruction surgery within two months were recruited from a Hong Kong public hospital. At baseline and two-month follow-up, patients completed measures of perceived autonomy support from doctors and physiotherapists and treatment motivation from SDT, social cognition constructs from the TPB factors, and adherence to the postsurgery rehabilitation program recommended by their surgeon. Results: Path analysis displayed good goodness-of-fit of the proposed model with the data (χ2 = 11.47 (df = 9), CFI = 0.98, TLI = 0.93, RMSEA = 0.06 [90% CI = 0.00; 0.10]) after controlling for age, gender, time of surgery, post-surgery rehabilitation, and injury severity. Consistent with hypotheses, perceived autonomy support from physiotherapist and autonomous treatment motivation directly and indirectly predicted the TPB constructs and treatment adherence. However, there was no association between perceived autonomy support from doctors and autonomous motivation. Conclusion: The integrated model was effective in explaining the psychological processes that relate to medical adherence. Findings also highlight the importance of the autonomy support from physiotherapists and provide evidence for potential intervention targets.
Abstract Protons of tens of keV can be resonantly scattered by electromagnetic ion cyclotron (EMIC) waves excited in the magnetosphere, resulting in proton precipitation down to the upper atmosphere. In this study, we report for the first time the ionospheric height-dependent ionization in response to EMIC-associated isolated proton aurora (IPA) using simultaneous space-borne and ground-based measurements. On 06 March 2019, the Polar Orbiting Environmental Satellites observed significant proton precipitation in the dusk sector (MLT ∼ 19), while ground-based magnetometers detected a clear signature of EMIC waves. Meanwhile, the conjugated all sky imager captured an IPA and the nearby Poker Flat incoherent scatter radar (PFISR) showed enhanced electron density in the E region, suggesting a potential consequence of the EMIC wave-driven proton precipitation. The Global Airglow model simulations confirmed the dominant impact of proton precipitation on the ionosphere and agreed well with PFISR observations. This study confirmed physical links from the magnetosphere to the ionosphere through EMIC-driven proton precipitation.
Pt/alpha-Fe2O3 nanocomposites were synthesized on fluorine-doped tin oxide (FTO) substrates by a sequential plasma enhanced-chemical vapor deposition (PE-CVD)/radio frequency (RF) sputtering approach, tailoring the overall Pt content as a function of sputtering time. The chemico-physical properties of the as-prepared systems were extensively investigated by means of complementary techniques, including X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), field emission-scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDXS), secondary ion mass spectrometry (SIMS), and optical absorption spectroscopy, and compared to those of the homologous Pt/alpha-Fe2O3 systems annealed in air prior and/or after sputtering. The obtained results evidenced that the material compositional, structural and morphological features, with particular regard to the Pt oxidation state and hematite nano-organization, could be finely tailored as a function of the adopted processing conditions. Pt/alpha-Fe2O3 systems were finally tested as photoanodes in photoelectrochemical (PEC) water splitting experiments, evidencing a remarkable interplay between functional performances and the above-mentioned material properties, as also testified by transient absorption spectroscopy (TAS) results.
Abstract Aims: To study the associations of lumbar developmental spinal stenosis (DSS) with low back pain (LBP), radicular leg pain, and disability. Methods: This was a cross-sectional study of 2,206 subjects along with L1-S1 axial and sagittal MRI. Clinical and radiological information regarding their demographics, workload, smoking habits, anteroposterior (AP) vertebral canal diameter, spondylolisthesis, and MRI changes were evaluated. Mann-Whitney U tests and chi-squared tests were conducted to search for differences between subjects with and without DSS. Associations of LBP and radicular pain reported within one month (30 days) and one year (365 days) of the MRI, with clinical and radiological information, were also investigated by utilizing univariate and multivariate logistic regressions. Results: Subjects with DSS had higher prevalence of radicular leg pain, more pain-related disability, and lower quality of life (all p < 0.05). Subjects with DSS had 1.5 (95% confidence interval (CI) 1.0 to 2.1; p = 0.027) and 1.8 (95% CI 1.3 to 2.6; p = 0.001) times higher odds of having radicular leg pain in the past month and the past year, respectively. However, DSS was not associated with LBP. Although, subjects with a spondylolisthesis had 1.7 (95% CI 1.1 to 2.5; p = 0.011) and 2.0 (95% CI 1.2 to 3.2; p = 0.008) times greater odds to experience LBP in the past month and the past year, respectively. Conclusions: This large-scale study identified DSS as a risk factor of acute and chronic radicular leg pain. DSS was seen in 6.9% of the study cohort and these patients had narrower spinal canals. Subjects with DSS had earlier onset of symptoms, more severe radicular leg pain, which lasted for longer and were more likely to have worse disability and poorer quality of life. In these patients there is an increased likelihood of nerve root compression due to a pre-existing narrowed canal, which is important when planning surgery as patients are likely to require multi-level decompression surgery.
One of the primary objectives of the Rosetta Plasma Consortium, a suite of five plasma instruments on-board the Rosetta spacecraft, is to observe the formation and evolution of plasma interaction regions at the comet 67P/Churyumov-Gerasimenko (67P/CG). Observations made between 2015 April and 2016 February show that solar wind-cometary plasma interaction boundaries and regions formed around 2015 mid-April and lasted through early 2016 January. At least two regions were observed, separated by an ion-neutral collisionopause boundary. The inner region was located on the nucleus side of the boundary and was characterized by low-energy water-group ions, reduced magnetic field pileup and enhanced electron densities. The outer region was located outside of the boundary and was characterized by reduced electron densities, water-group ions that are accelerated to energies above 100 eV and enhanced magnetic field pileup compared to the inner region. The boundary discussed here is outside of the diamagnetic cavity and shows characteristics similar to observations made on-board the Giotto spacecraft in the ion pileup region at 1P/Halley. We find that the boundary is likely to be related to ion-neutral collisions and that its location is influenced by variability in the neutral density and the solar wind dynamic pressure.
We present multiepoch, parsec-scale core brightness temperature observations of 447 active galactic nucleus (AGN) jets from the MOJAVE and 2 cm Survey programs at 15 GHz from 1994 to 2019. The brightness temperature of each jet over time is characterized by its median value and variability. We find that the range of median brightness temperatures for AGN jets in our sample is much larger than the variations within individual jets, consistent with Doppler boosting being the primary difference between the brightness temperatures of jets in their median state. We combine the observed median brightness temperatures with apparent jet speed measurements to find the typical intrinsic Gaussian brightness temperature of 4.1( ± 0.6) × 1010 K, suggesting that jet cores are at or below equipartition between particle and magnetic field energy in their median state. We use this value to derive estimates for the Doppler factor for every source in our sample. For the 309 jets with both apparent speed and brightness temperature data, we estimate their Lorentz factors and viewing angles to the line of sight. Within the BL Lac optical class, we find that high-synchrotron-peaked BL Lacs have smaller Doppler factors, lower Lorentz factors, and larger angles to the line of sight than intermediate and low-synchrotron-peaked BL Lacs. We confirm that AGN jets with larger Doppler factors measured in their parsec-scale radio cores are more likely to be detected in ? rays, and we find a strong correlation between ?-ray luminosity and Doppler factor for the detected sources.
Abstract Background and purpose: Protein tyrosine phosphatase receptor type Q (PTPRQ) was extracted from the cerebrospinal fluid (CSF) of patients with probable idiopathic normal‐pressure hydrocephalus (iNPH) by proteome analysis. We aimed to assess the feasibility of using CSF PTPRQ concentrations for the additional diagnostic criterion of iNPH in Japanese and Finnish populations. Methods: We compared PTPRQ concentrations among patients with probable iNPH and neurologically healthy individuals (normal control [NC] group), patients with normal‐pressure hydrocephalus (NPH) of acquired and congenital/developmental aetiologies, patients with Alzheimer’s disease and patients with Parkinson’s disease in a Japanese analysis cohort. A corresponding iNPH group and NC group in a Finnish cohort was used for validation. Patients in the Finnish cohort who underwent biopsy were classified into two groups based on amyloid and/or tau deposition. We measured PTPRQ expression levels in autopsied brain specimens of iNPH patients and the NC group. Results: Cerebrospinal fluid PTPRQ concentrations in the patients with NPH of idiopathic, acquired and congenital/developmental aetiologies were significantly higher than those in the NC group and those with Parkinson’s disease, but iNPH showed no significant differences when compared with those in the Alzheimer’s disease group. For the patients with iNPH, the area under the receiver‐operating characteristic curve was 0.860 in the Japanese iNPH and 0.849 in the Finnish iNPH cohorts. Immunostaining and in situ hybridization revealed PTPRQ expression in the ependymal cells and choroid plexus. It is highly possible that the elevated PTPRQ levels in the CSF are related to ependymal dysfunction from ventricular expansion. Conclusions: Cerebrospinal fluid PTPRQ levels indicated the validity of this assay for auxiliary diagnosis of adult chronic hydrocephalus.
We evaluated the accuracy of biology informed genomic prediction for dry matter intake in 2,162 Dutch Holstein cows. Sequence variants were selected from meta-analyses including GWAS summary statistics for QTL and metabolomic QTL in several dairy and crossbred beef populations. Selected variants were prioritized in GBLUP models in a five-fold cross-validation. The accuracies were compared to genomic prediction based on routine 50k genotype data. The average accuracy for the 50k scenario was 0.683. Adding selected sequence variants in the GBLUP model did not improve the accuracies for dry matter intake. Next steps will include testing Bayesian variable selection methods to prioritize variants in genomic prediction for dry matter intake.
Heavy-ion microbeams are employed for probing the radiation-sensitive regions in commercial SiC VD-MOSFETs with micrometer accuracy. By scanning the beam spot over the die, a spatial periodicity was observed in the leakage current degradation, reflecting the striped structure of the power MOSFET investigated. Two different mechanisms were observed for degradation. At low drain bias (gate and source grounded) only the gate-oxide (at JFET or neck region) is contributing in the ion-induced leakage current. For exposures at drain-source bias voltages higher than a specific threshold, additional higher drain leakage current is observed in the p-n junction region. This provides useful insights for the understanding of basic phenomena of Single Event Effects in SiC power devices.
Abstract Hydrogenated titanium dioxide has attracted intensive research interests in pollutant removal applications due to its high photocatalytic activity. Herein, we demonstrate hydrogenated TiO2 nanofibers (H:TiO2 NFs) with a core-shell structure prepared by the hydrothermal synthesis and subsequent heat treatment in hydrogen flow. H:TiO2 NFs has excellent solar light absorption and photogenerated charge formation behavior as confirmed by optical absorbance, photo-Kelvin force probe microscopy and photoinduced charge carrier dynamics analyses. Photodegradation of various organic dyes such as methyl orange, rhodamine 6G and brilliant green is shown to take place with significantly higher rates on our novel catalyst than on pristine TiO2 nanofibers and commercial nanoparticle based photocatalytic materials, which is attributed to surface defects (oxygen vacancy and Ti3+ interstitial defect) on the hydrogen treated surface. We propose three properties/mechanisms responsible for the enhanced photocatalytic activity, which are: (1) improved absorbance allowing for increased exciton generation, (2) highly crystalline anatase TiO2 that promotes fast charge transport rate, and (3) decreased charge recombination caused by the nanoscopic Schottky junctions at the interface of pristine core and hydrogenated shell thus promoting long-life surface charges. The developed H:TiO2 NFs can be helpful for future high performance photocatalysts in environmental applications.