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Abstract A spring-fall asymmetry is observed in daytime amplitude values of very low frequency (VLF) radio wave signals propagating over the North Atlantic during 2011–2019. We explore the processes behind this asymmetry by comparing against mesospheric mean temperatures and the semidiurnal solar tide (S2) in mesospheric winds. The solar radiation influence on VLF subionospheric propagation was removed from the daytime VLF amplitude values, isolating the fall-effect. Similarly, the symmetric background level was removed from mesospheric mean temperatures undertaking comparable analysis. During fall, all three analyzed parameters experience significant deviation from their background levels. The VLF amplitude variation during spring is explained by the seasonal variation in solar illumination conditions, while the fall-effect can be interpreted as a mean zonal wind reversal associated with both a S2 enhancement, and temperature reductions. Decreases in temperature can produce decreases in collision frequency, reducing VLF signal absorption, driving the observed VLF asymmetry.
An interface between LaAlO3 and SrTiO3 (LAO/STO) may host two-dimensional superconductivity, strong spin-orbit coupling, and magnetic ordering. There are indications that the interfacial superconducting layer is nonhomogeneous at the nanoscale. The presence of inhomogeneities may have strong implications on the superconducting transport properties and lead to formation of weak links between superconducting regions. In this paper, we report on the temperature and magnetic field dependence of superconducting transport in single nanowires and nanorings fabricated in a LAO/STO interface. The analysis of data proves that our nanostructures behave like uniform superconducting filaments carrying a critical current close to the theoretical Ginzburg-Landau depairing limit. Furthermore, we unexpectedly find an enhancement of the critical current of LAO/STO nanowires and nanorings at low temperature when a magnetic field is applied. Our results point towards the coexistence of a homogeneous interfacial superconductivityand spatially separated magnetism at the LAO/STO interface.
Abstract Stable oxygen isotope (δ18O) compositions from vertebrate tooth enamel are widely used as biogeochemical proxies for paleoclimate. However, the utility of enamel oxygen isotope values for environmental reconstruction varies among species. Herein, we evaluate the use of stable oxygen isotope compositions from pronghorn (Antilocapra americana Gray, 1866) enamel for reconstructing paleoclimate seasonality, an elusive but important parameter for understanding past ecosystems. We serially sampled the lower third molars of recent adult pronghorn from Wyoming for δ18O in phosphate (δ18OPO4) and compared patterns to interpolated and measured yearly variation in environmental waters as well as from sagebrush leaves, lakes, and rivers (δ18Ow). As expected, the oxygen isotope compositions of phosphate from pronghorn enamel are enriched in 18O relative to environmental waters. For a more direct comparison, we converted δ18Ow values into expected δ18OPO4* values (δ18OW-PO4*). Pronghorn δ18OPO4 values from tooth enamel record nearly the full amplitude of seasonal variation from Wyoming δ18OW-PO4* values. Furthermore, pronghorn enamel δ18OPO4 values are more similar to modeled δ18OW-PO4* values from plant leaf waters than meteoric waters, suggesting that they obtain much of their water from evaporated plant waters. Collectively, our findings establish that seasonality in source water is reliably reflected in pronghorn enamel, providing the basis for exploring changes in the amplitude of seasonality of ancient climates. As a preliminary test, we sampled historical pronghorn specimens (1720 ± 100 AD), which show a mean decrease (a shift to lower values) of 1–2‰ in δ18 OPO4 compared to the modern specimens. They also exhibit an increase in the δ18O amplitude, representing an increase in seasonality. We suggest that the cooler mean annual and summer temperatures typical of the 18th century, as well as enhanced periods of drought, drove differences among the modern and historical pronghorn, further establishing pronghorn enamel as excellent sources of paleoclimate proxy data.
Background Age-related cognitive decline may be delayed with appropriate interventions if those at high risk can be identified prior to clinical symptoms arising. Gait variability assessment has emerged as a promising candidate prognostic indicator, however, it remains unclear how sensitive gait variability is to early changes in cognitive abilities. Research question Do community-dwelling adults over 65 years of age with subjective memory complaints differ from those with no subjective memory concerns in terms of laboratory-measured or free-living gait variability? Methods This cross-sectional study recruited 24 (age = 73.5(SD 6.4) years) community-dwelling people with subjective memory complaints and twenty seven (age = 70.9(4.3) years) individuals with no subjective memory concerns. A sample of 9 individuals with diagnosed mild dementia were also assessed (age = 86.5(7.0) years). Gait variability was assessed in a laboratory during walking at preferred pace (single-task) and while counting backward by seven (dual-task). Sixteen passes over a 4.88 m walkway in each condition were recorded and step length and duration variability was analysed. Free-living gait was assessed with a waist-worn accelerometer by identifying gait bouts of at least one min duration, and the mean multiscale sample entropy in one mins non-overlapping epochs is reported. Statistical inferences were based on analysis of variance using sex and group as the factors. Results No difference between those with subjective memory complaints and those without were observed in either laboratory- or free-living gait variability estimates. Both laboratory- and free-living gait variability were higher in those with mild dementia compared to the other groups. Significance Assuming that subjective memory complaints are on the pathway from cognitively intact to cognitively frail, the findings raise the hypothesis that subjective memory complaints occur earlier in the pathophysiology than measurable changes in laboratory or free living gait. Alternatively the gait variability assessments utilised may have been too insensitive.
Abstract The field of structural engineering is vast, spanning areas from the design of new infrastructure to the assessment of existing infrastructure. From the onset, traditional entry-level university courses teach students to analyse structural responses given data including external forces, geometry, member sizes, restraint, etc.—characterizing a forward problem (structural causalities → structural response). Shortly thereafter, junior engineers are introduced to structural design where they aim to, for example, select an appropriate structural form for members based on design criteria, which is the inverse of what they previously learned. Similar inverse realizations also hold true in structural health monitoring and a number of structural engineering sub-fields (response → structural causalities). In this light, we aim to demonstrate that many structural engineering sub-fields may be fundamentally or partially viewed as inverse problems and thus benefit via the rich and established methodologies from the inverse problems community. To this end, we conclude that the future of inverse problems in structural engineering is inexorably linked to engineering education and machine learning developments.
This work describes the utilization of an injected 23Na1þ ion beam as a diagnostics of the helium plasma of a charge breeder electron cyclotron resonance ion source. The obtained data allows estimating the upper limit for the ion-ion collision mean-free path of the incident sodium ions, the lower limit of ion-ion collision frequencies for all charge states of the sodium ions and the lower limit of the helium plasma density. The ion-ion collision frequencies of high charge state ions are shown to be at least on the order of 1–10 MHz and the plasma density is estimated to be on the order of 1011 cm−3 or higher. The experimental results are compared to simulations of the 23Na1þ capture into the helium plasma. The results indicate that the lower breeding efficiency of light ions in comparison to heavier elements is probably due to different capture efficiencies in which the in-flight ionization of the incident 1þ ions plays a vital role.
The interband optical transitions in cube-on-cube-type epitaxial ferroelectric NaNbO3 thin films and a reference antiferroelectric NaNbO3 crystal are studied in the spectral range of 0.74–9 eV using variable-angle spectroscopic ellipsometry. The energies and the types of the transitions in the films are found to differ significantly from those in the crystal and to vary with epitaxial strain. The results are discussed in terms of epitaxial effects, including higher crystal symmetry, anisotropic lattice strain, and ferroelectric polarization in the NaNbO3 films compared to the crystal.
Abstract This paper reports a design science research (DSR) study that develops, demonstrates and evaluates a set of design principles for information systems (IS) that utilise learning analytics to support learning and teaching in higher education. The initial set of design principles is created from theory-inspired conceptualisation based on the literature, and they are evaluated and revised through a DSR process of demonstration and evaluation. We evaluated the developed artefact in four courses with a total enrolment of 1,173 students. The developed design principles for learning analytics information systems (LAIS) to establish a foundation for further development and implementation of learning analytics to support learning and teaching in higher education.
Abstract Background: In recent decades, there has been an increase in the prevalence of childhood overweight in most high‐income countries. Within northern Europe, prevalence tends to be higher in the UK compared with the Scandinavian countries. We aimed to study differences in body mass index (BMI) trajectories between large cohorts of children from UK and Scandinavian populations. Methods: We compared BMI trajectories in participants from the English Avon Longitudinal Study of Parents and Children born in 1991–1993 (ALSPAC) (N = 6517), the Northern Finland Birth Cohorts born in 1966 (NFBC1966) (N = 3321) and 1986 (NFBC1986) (N = 4764), and the Danish Aarhus Birth Cohort born in 1990–1992 (ABC) (N = 1920). We used multilevel models to estimate BMI trajectories from 2 to 18 years. We explored whether cohort differences were explained by maternal BMI, height, education or smoking during pregnancy and whether differences were attributable to changes in the degree of skew in the BMI distribution. Results: Differences in mean BMI between the cohorts were small but emerged early and persisted in most cases across childhood. Girls in ALSPAC had a higher BMI than all other cohorts throughout childhood, e.g. compared with the NFBC1986 BMI was 2.2–3.5% higher. For boys, the difference emerging over time (comparing the two NFBC’s) exceeded the differences across populations (comparing NFBC1986, ABC and ALSPAC). BMI distribution demonstrated increasing right skew with age. Conclusion: Population‐level differences between cohorts were small, tended to emerge very early, persisted across childhood, and demonstrated an increase in the right‐hand tail of the BMI distribution.
The rate and temporal pattern of neural spiking each have the potential to influence computation. In the cerebellum, it has been hypothesized that the irregularity of interspike intervals in Purkinje cells affects their ability to transmit information to downstream neurons. Accordingly, during oculomotor behavior in mice and rhesus monkeys, mean irregularity of Purkinje cell spiking varied with mean eye velocity. However, moment-to-moment variations revealed a tight correlation between eye velocity and spike rate, with no additional information conveyed by spike irregularity. Moreover, when spike rate and irregularity were independently controlled using optogenetic stimulation, the eye movements elicited were well-described by a linear population rate code with 3–5 ms temporal precision. Biophysical and random-walk models identified biologically realistic parameter ranges that determine whether spike irregularity influences responses downstream. The results demonstrate cerebellar control of movements through a remarkably rapid rate code, with no evidence for an additional contribution of spike irregularity.
Abstract Thin hexagonal boron nitride films with a thickness of several monoatomic layers have been manufactured by splitting of bulk samples in an ultrasonic bath. The transmission, reflection, and photoluminescence spectra of such films are studied. The spectral dependences of linear and circular polarization of light passing through the sample are measured. Scanning electron microscopy investigation demonstrates homogeneity of the obtained samples. However, investigation of Stokes parameters of light passing through the sample makes it possible to reveal hidden anisotropy of optical properties of these films.
Abstract Polarization-control devices have attracted considerable interest, however, most of the polarization converters operating at lower frequencies have a heavy design and narrow bandwidth which limits their practical applications. Here we report a simple design of an ultra-wideband and lightweight polarization converter for applications in the S- and C-bands. The proposed converter is designed based on a metasurface structure with the dielectric layer modified to hollow structure to obtain a lightweight design even working at such low frequency. Theoretical analysis and simulation results indicate that the converter can convert the orthogonal polarization transformation of reflected wave. Furthermore, the measurement results show good agreement with the simulation results. The proposed polarization converter can achieve a polarization conversion ratio above 90% in an ultra-wide frequency range from 2 to 8.45 GHz due to multi-resonance modes. These performances are going beyond state of the art in terms of bandwidth and lightweight design, thus it can be applied in various applications in the operating bands.
Abstract Compounds 13 and 14 were evaluated against eleven PARP isoforms to reveal that both 13 and 14 were more potent and isoform-selective towards inhibiting tankyrases (TNKSs) than the “standard” inhibitor 1 (XAV939)5, i.e. IC50 = 100 pM vs. TNKS2 and IC50 = 6.5 μM vs. PARP1 for 14. In cellular assays, 13 and 14 inhibited Wnt-signaling, enhanced insulin-stimulated glucose uptake and inhibited the proliferation of DLD-1 colorectal adenocarcinoma cells to a greater extent than 1.
We have obtained a smooth time series for the electric vector position angle (EVPA) of the blazar OJ 287 at centimeter wavelengths, by making ±nπ adjustments to archival values from 1974 to 2016. The data display rotation reversals in which the EVPA rotates counterclockwise for ∼180° and then rotates clockwise by a similar amount. The timescale of the rotations is a few weeks to a year, and the scale for a double rotation, including the reversal, is 1-3 yr. We have seen four of these events in 40 yr. A model consisting of two successive outbursts in polarized flux density, with EVPAs counterrotating, superposed on a steady polarized jet, can explain many of the details of the observations. Polarization images support this interpretation. The model can also help to explain similar events seen at optical wavelengths. The outbursts needed for the model can be generated by the supermagnetosonic jet model of Nakamura et al. and Nakamura & Meier, which requires a strong helical magnetic field. This model produces forward and reverse pairs of fast and slow MHD waves, and the plasma inside the two fast/slow pairs rotates around the jet axis, but in opposite directions.
Abstract Purpose: Soil diaspore banks of bryophytes are poorly known in tundra grasslands, yet can be important for the maintenance of local bryophyte assemblages. We examined the effects of fertilization and grazing exclusion on above-ground bryophyte assemblages and soil diaspore banks in a tundra grassland. Methods: We collected soil diaspore samples and recorded the cover of above-ground bryophytes from a full-factorial experiment with NPK fertilization and grazing exclusion treatments (a Nutrient Network site in NW Finland). Soil diaspore samples were germinated on trays in a greenhouse. We analyzed the compositions of diaspore bank assemblages and of above-ground assemblages and assessed their responses to the experimental treatments. Results: The diaspore bank contained c. 50% of taxa found in above-ground assemblages; 26 bryophyte taxa germinated from the diaspore bank, while 40 taxa were found in the above-ground assemblages. These communities had distinct species compositions: the diaspore bank was dominated by Pohlia nutans, while above-ground assemblages were dominated by several species. NPK fertilization and grazing exclusion had negative effects on bryophyte richness and cover in above-ground assemblages, and weaker effects on these responses in the diaspore bank. Conclusion: Soil diaspore banks comprise about half of the bryophyte taxa encountered in above-ground assemblages. Bryophyte diaspore banks are more buffered against nutrient enrichment and grazing exclusion than above-ground assemblages, suggesting that diaspore banks may enhance persistence and recovery of local bryophyte assemblages from environmental changes.
Abstract We proposed several energy-efficient resource allocation algorithms for the downlink of an orthogonal frequency-division-multiple-access (OFDMA) based femtocell heterogeneous networks (HetNets). Heterogeneous QoS and fairness in rate are investigated in the proposed resource allocation problem. A dense deployment of femtocells in the coverage area of a central macrocell is considered and energy usage of both femtocell and macrocell users are optimized simultaneously. We aim to maximize the weighted sum of the individual energy efficiencies (WSEEMax) and the network energy efficiency (NEEMax) while satisfying the following: (1) minimum throughput for delay-sensitive (DS) users, (2) fairness constraint for delay-tolerant (DT) users, (3) required constraints of OFDMA systems. The problem is formulated in three different forms: mixed 0—1 integer programming formulation, time-sharing formulation and sparsity-inducing formulation. The proposed resource block (RB) and power optimization problems are combinatorial and highly non-convex due to the fractional form of the objective function, the integer constraint of OFDMA RBs and non-affine fairness. We adopt the successive convex approximation (SCA) approach and transform the problems into a sequence of convex subproblems. With the proposed algorithms, we show that the overall joint RB and power allocation schemes converge to suboptimal solutions. Numerical examples confirm the merits of the proposed algorithms.
Abstract Revitalizing Viena Karelian dialect by finding new ways of learning and teaching Karelian culture and language is important. Karelian is a Finnic language and it is the closest linguistic relative to Finnish. It is spoken in Finland and Russia and its dialects must not be mixed up with Karelian (south-eastern) dialects of Finnish. It is estimated that there are approximately 5,000 speakers of Karelian language in Finland and about 20,000 persons can understand it to some extent. According to the 2002 census, there are approximately 53,000 Karelian speakers in Russia. In both countries, speakers are mainly elderly. Therefore, the gamification approach was used to design and develop an educational game from non-gaming contexts for aiming to prevent language or its dialects extinction. In this study, a ”Let’s Learn Karelian” game prototype was designed for learning Viena Karelian dialect where English and Finnish users can use it and learn in a fun and effective way. A non functional prototype was developed with the Microsoft PowerPoint in a mobile context to get preliminary feedback from users. A relatively small user experience study with five participants was conducted in the early phase of development at the University of Oulu. Based on the feedback, the game prototype was perceived as visually pleasant, creative, easy to use, playful and entertaining. This paper also briefly introduces our new functional ”Learn Viena Karelian” prototype. According to our findings there is a need to develop various games for revitalizing Viena Karelian dialect and culture.
We consider the diffusion of Brownian particles in one-dimensional periodic potentials as a test bench for the recently proposed stochastic path integral hyperdynamics (PIHD) scheme [Chen and Horing, J. Chem. Phys. 126, 224103 (2007)]. First, we consider the case where PIHD is used to enhance the transition rate of activated rare events. To this end, we study the diffusion of a single Brownian particle moving in a spatially periodic potential in the high-friction limit at low temperature. We demonstrate that the boost factor as compared to straight molecular dynamics (MD) has nontrivial behavior as a function of the bias force. Instead of growing monotonically with the bias, the boost attains an optimal maximum value due to increased error in the finite path sampling induced by the bias. We also observe that the PIHD method can be sensitive to the choice of numerical integration algorithm. As the second case, we consider parallel resampling of multiple bias force values in the case of a Brownian particle in a periodic potential subject to an external ac driving force. We confirm that there is no stochastic resonance in this system. However, while the PIHD method allows one to obtain data for multiple values of the ac bias, the boost with respect to MD remains modest due to the simplicity of the equation of motion in this case.
Superstructured colloidal materials exploit the synergies between components to develop new or enhanced functions. Cohesion is a primary requirement for scaling up these assemblies into bulk materials, and it has only been fulfilled in case-specific bases. Here, we demonstrate that the topology of nanonetworks formed from cellulose nanofibrils (CNFs) enables robust superstructuring with virtually any particle. An intermixed network of fibrils with particles increases the toughness of the assemblies by up to three orders of magnitude compared, for instance, to sintering. Supramolecular cohesion is transferred from the fibrils to the constructs following a power law, with a constant decay factor for particle sizes from 230 nm to 40 μm. Our findings are applicable to other nanofiber dimensions via a rationalization of the morphological aspects of both particles and nanofibers. CNF-based cohesion will move developments of functional colloids from laboratory-scale toward their implementation in large-scale nanomanufacturing of bulk materials.
Abstract Unlike in land plants, photosynthesis in many aquatic plants relies on bicarbonate in addition to carbon dioxide (CO2) to compensate for the low diffusivity and potential depletion of CO2 in water. Concentrations of bicarbonate and CO2 vary greatly with catchment geology. In this study, we investigate whether there is a link between these concentrations and the frequency of freshwater plants possessing the bicarbonate use trait. We show, globally, that the frequency of plant species with this trait increases with bicarbonate concentration. Regionally, however, the frequency of bicarbonate use is reduced at sites where the CO2 concentration is substantially above the air equilibrium, consistent with this trait being an adaptation to carbon limitation. Future anthropogenic changes of bicarbonate and CO2 concentrations may alter the species compositions of freshwater plant communities.
In this work we study ordinary muon capture (OMC) on 24Mg from a first-principles perspective. Starting from a particular two- and three-nucleon interaction derived from chiral effective field theory, we use the valence-space in-medium similarity renormalization group (VS-IMSRG) framework to construct effective Hamiltonians and muon-capture operators, which nonperturbatively account for many-body physics outside the valence space. The obtained nuclear matrix elements are compared against those from the phenomenological shell model. The impact of including the correlations from the nuclear shell model (NSM) as well as including the induced two-body part is studied in detail. Furthermore, the effects of realistic bound-muon wave function on the operators is studied. Finally, predictions for capture rates to the lowest excited states in 24Na are given and compared with available data. It is found that the spectroscopic properties of 24Mg and its OMC daughter 24Na are fairly well described by both the NSM and VS-IMSRG, and that the effect of the hadronic two-body currents significantly reduces the OMC rates. Both models have some difficulties in matching the measured OMC rates, especially for the 2+ final states. This calls for further studies in other light nuclei with available OMC data.
Abstract We present Swarm satellite and EISCAT radar observations of electrodynamical parameters in the midnight sector at high latitudes. The most striking feature is a plasma flow channel located equatorward of the polar cap boundary within the dawn convection cell. The flow channel is 1.5° wide in latitude and contains southward electric field of 150 mV/m, corresponding to eastward plasma velocities of 3,300 m/s in the F‐region ionosphere. The theoretically computed ion temperature enhancement produced by the observed ion velocity is in accordance with the measured one by the EISCAT radar. The total width of the auroral oval is about 10° in latitude. While the poleward part is electric field dominant with low conductivity and the flow channel, the equatorward part is conductivity dominant with at least five auroral arcs. The main part of the westward electrojet flows in the conductivity dominant part, but it extends to the electric field dominant part. According to Kamide and Kokubun (1996), the whole midnight sector westward electrojet is expected to be conductivity dominant, so the studied event challenges the traditional view. The flow channel is observed after substorm onset. We suggest that the observed flow channel, which is associated with a 13‐kV horizontal potential difference, accommodates increased nightside plasma flows during the substorm expansion phase as a result of reconnection in the near‐Earth magnetotail.
Abstract Software Defined Networking (SDN) is a driving technology for enabling the 5th Generation of mobile communication (5G) systems offering enhanced network management features and softwarization. This paper concentrates on reducing the operating expenditure (OPEX) costs while i) increasing the quality of service (QoS) by leveraging the benefits of queuing and multi-path forwarding in OpenFlow, ii) allowing an operator with an SDN-enabled network to efficiently allocate the network resources considering mobility, and iii) reducing or even eliminating the need for over-provisioning. For achieving these objectives, a QoS aware network configuration and multipath forwarding approach is introduced that efficiently manages the operation of SDN enabled open virtual switches (OVSs). This paper proposes and evaluates three solutions that exploit the strength of QoS aware routing using multiple paths. While the two first solutions provide optimal and approximate optimal configurations, respectively, using linear integer programming optimization, the third one is a heuristic that uses Dijkstra short-path algorithm. The obtained results demonstrate the performance of the proposed solutions in terms of OPEX and execution time.
Abstract Three-dimensional space-time velocity filters may be used to enhance dynamic passband objects of interest in videos while attenuating moving interfering objects based on their velocities. In this paper, we show that the attenuation of interfering stopband objects may be significantly improved using recently proposed shifted-velocity filters. It is shown that an improvement of approximately 20 dB in signal-to-interference ratio may be achieved for stopband to passband velocity differences of only 1 pixels/frame. More importantly, this improvement is achieved without increasing the computational complexity.
Abstract We used historical DNA samples to examine the history of a native horse breed, the Finnhorse. Samples were collected from private collections, museums, schools and excavations, representing the times prior to, during, and after the foundation of the breed; from the end of the 19th century and throughout the 20th century. We sequenced a fragment of mitochondrial DNA from these historical samples to study the history and evolution of maternal lineages of horses back to the early days of the breed, compared the mitochondrial DNA sequence diversity of different historical periods and modern day Finnhorses, estimated the effective population sizes, and searched for both temporal and geographic population genetic structure. We observed high maternal haplotype and nucleotide diversity at the time during the foundation of the breed, and a decrease in both measures during 1931–1970. In addition, we observed losses of some haplotypes present in the early stages of the breed. There was only slight evidence of geographical or temporal population structure. This study is, to our knowledge, the first to use such temporal sampling to reveal the history of a specific animal breed.
Abstract Decline in both telomere length and physical fitness over the life course may contribute to increased risk of several chronic diseases. The relationship between telomere length and aerobic and muscular fitness is not well characterized. We examined whether there are cross-sectional associations of mean relative leukocyte telomere length (LTL) with objective measures of aerobic fitness, muscle strength, and muscle endurance, using data on 31-year-old participants of the Northern Finland Birth Cohort 1966 (n = 4,952–5,205, varying by exposure-outcome analysis). Aerobic fitness was assessed by means of heart rate measurement following a standardized submaximal step test; muscular fitness was assessed by means of a maximal isometric handgrip strength test and a test of lower-back trunk muscle endurance. Longer LTL was associated with higher aerobic fitness and better trunk muscle endurance in models including adjustment for age, sex, body mass index, socioeconomic position, diet, smoking, alcohol consumption, physical activity level, and C-reactive protein. In a sex-stratified analysis, LTL was not associated with handgrip strength in either men or women. LTL may relate to aspects of physical fitness in young adulthood, but replication of these findings is required, along with further studies to help assess directions and causality in these associations.
Abstract Human endometrium undergoes cyclic regeneration involving stem/progenitor cells, but the role of resident endometrial mesenchymal stem cells (eMSC) as progenitors of endometrial stromal fibroblasts (eSF) has not been definitively demonstrated. In endometriosis, eSF display progesterone (P4) resistance with impaired decidualization in vivo and in vitro. To investigate eMSC as precursors of eSF and whether endometriosis P4 resistance is inherited from eMSC, we analyzed transcriptomes of eutopic endometrium eMSC and eSF isolated by fluorescence-activated cell sorting (FACS) from endometriosis (eMSCendo, eSFendo) and controls (eMSCcontrol, eSFcontrol) and their derived primary cultures. Differentially expressed lineage-associated genes (LG) of FACS-isolated eMSC and eSF were largely conserved in endometriosis. In culture, eSFcontrol maintained in vitro expression of a subset of eSF LG and decidualized in vitro with P4. The eMSCcontrol cultures differentiated in vitro to eSF lineage, down-regulating eMSC LG and up-regulating eSF LG, showing minimal transcriptome differences versus eSFcontrol cultures and decidualizing in vitro. Cultured eSFendo displayed less in vitro LG stability and did not decidualize in vitro. In vitro, eMSCendo differentiated to eSF lineage but showed more differentially expressed genes versus eSFendo cultures, and did not decidualize in vitro, demonstrating P4 resistance inherited from eMSCendo. Compared to controls, cultures from tissue-derived eSFendo uniquely had a pro-inflammatory phenotype not present in eMSCendo differentiated to eSF in vitro, suggesting divergent niche effects for in vivo versus in vitro lineage differentiation. These findings substantiate eMSC as progenitors of eSF and reveal eSF in endometriosis as having P4 resistance inherited from eMSC and a pro-inflammatory phenotype acquired within the endometrial niche.
Magnesium alloys, among the lightest structural materials, represent excellent candidates for lightweight applications. However, industrial applications remain limited due to relatively low strength and ductility. Solid solution alloying has been shown to enhance Mg ductility and formability at relatively low concentrations. Zn solutes are significantly cost effective and common. However, the intrinsic mechanisms by which the addition of solutes leads to ductility improvement remain controversial. Here, by using a high throughput analysis of intragranular characteristics through data science approaches, we study the evolution of dislocation density in polycrystalline Mg and also, Mg–Zn alloys. We apply machine learning techniques in comparing electron back-scatter diffraction (EBSD) images of the samples before/after alloying and before/after deformation to extract the strain history of individual grains, and to predict the dislocation density level after alloying and after deformation. Our results are promising given that moderate predictions (coefficient of determination R2 ranging from 0.25 to 0.32) are achieved already with a relatively small dataset (∼ 5000 sub-millimeter grains).
Using stacking of images obtained at different epochs, we studied the variability properties of linear polarization of active galactic nucleus (AGN) jets on parsec-scales. Our sample is drawn from the MOJAVE programme, and consists of 436 AGNs manifesting core-jet morphology and having at least five VLBA observing epochs at 15 GHz from 1996 January through 2019 August, with some additional archival VLBA data reduced by us. We employed a stacking procedure and constructed maps of (i) standard deviation of fractional polarization and electric vector position angle (EVPA) over epochs as the measure of variability and (ii) median polarization degree to quantify typical values in time. The distributions of these values along and across the jet were analysed for the whole sample for the first time. We found that core EVPA variability is typically higher than that of the jet, presumably due to component blending and outflow bends in the core. The BL Lacertae object cores have lower EVPA variability, compared to that of quasars, possibly due to lower Faraday rotation measure, suggesting a stronger ordered magnetic field component. The EVPA becomes more stable down the jet. Most of the sources showing this trend have a time coverage of more than 12 yr and at least 15 epochs. The possible cause could be the increase of stability in the magnetic field direction, reflecting an increase in the fraction of the magnetic field that is ordered. There are no significant optical-class-dependent or spectral-class-dependent relations in the EVPA variability properties in AGN jets.
Abstract Food taboos are observed in all traditional societies. In Cameroon, various taboos ranging from food to religious and social have significant impact on the diet of the people. Specific food items are regarded differently by different communities. While in certain communities, some food items are seen as fit for consumption, others deem it unfit. Although food taboos related to culture are more subject to change due to the level of literacy that prevails in the society and due to cultural contacts, violators of taboos suffer grievous consequences. Methods used included key informant interviews, focus group discussions and observations in all studied communities. The objective of the study is to understand how culture (food taboos) influences consumption patterns in traditional communities and the impact of disobedience on the people. This study of Cameroon food taboos has showed that dietary rules and regulations govern particular phases of life and is associated with special events like pregnancy, childbirth, lactation etc. In traditional societies, festivities such as hunting, wedding, and funeral are marked by specific food items. Punishments to violation of food taboos vary across food items and communities as what are considered a taboo in one community is not a taboo in another. Food taboo in some communities is considered as a way to maintain identity creating a sense of belonging.
Abstract We report progress on the ongoing recalibration of the Wolf sunspot number (SN) and group-sunspot number (GN) following the release of version 2.0 of SN in 2015. This report constitutes both an update of the efforts reported in the 2016 Topical Issue of Solar Physics and a summary of work by the International Space Science Institute (ISSI) International Team formed in 2017 to develop optimal SN and GN reconstruction methods while continuing to expand the historical sunspot-number database. Significant progress has been made on the database side while more work is needed to bring the various proposed SN and (primarily) GN reconstruction methods closer to maturity, after which the new reconstructions (or combinations thereof) can be compared with (a) “benchmark” expectations for any normalization scheme (e.g., a general increase in observer normalization factors going back in time), and (b) independent proxy data series such as F10.7 and the daily range of variations of Earth’s undisturbed magnetic field. New versions of the underlying databases for SN and GN will shortly become available for years through 2022 and we anticipate the release of the next versions of these two time series in 2024.
The interplay of flows and turbulence in Ohmic FT-2 tokamak plasmas is analysed via gyrokinetic simulations with the flux-driven ELMFIRE code. The simulation predictions agree qualitatively with analytical estimates for the scaling of the neoclassical radial electric field as a function of collisionality for ad hoc parameters. For the experimental parameters, the global full-f modeling agrees well with the analytical estimates in a neoclassical setting, while including kinetic electrons and impurities has a small impact. Allowing turbulence to develop modifies the flow profile through relaxation of profiles caused by turbulent transport, non-adiabatic response of passing electrons around rational surfaces, and turbulent flow drive. Geodesic acoustic mode (GAM) is the main zonal flow component in the simulations, and its frequency and amplitude agree with theoretical predictions and experimental measurements. In the simulations, the non-linear energy transfer from the turbulence to the flows through the Reynolds force is balanced by the collisional flow dissipation. Temporal relationship between the oscillating flow, Reynolds force, and turbulent particle flux is consistent with the fundamental physics picture of GAM modulating turbulent transport on the time scale of the mode. Experimental evidence also suggests anti-correlation of GAM amplitude and turbulent fluctuations.
Abstract Objectives: To assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg. Design: Multicenter, open-label, phase 3 trial. Setting: Sixty-nine sites in Europe and Russia. Population: Sexually active women aged 18–50 years with regular menstrual cycles and body mass index ≤35 kg/m2. Methods: E4/DRSP was administered in a 24 active/4 placebo regimen for up to 13 cycles. Visits were scheduled during Cycles 2, 4, 7 and 10 and after completing treatment during which adverse events (AEs) were collected. Participants recorded medication intake, vaginal bleeding/spotting, use of other contraceptive methods and sexual intercourse on a daily diary. Main outcome measures: Pearl Index (PI) for women 18–35 years (overall and method-failure), bleeding pattern and AEs. Results: A total of 1553 women aged 18–50 years, including 1353 from 18 to 35 years old, received the study medication. PI was 0.47 pregnancies/100 woman-years (95% CI 0.15–1.11); method failure PI was 0.29 pregnancies/100 woman-years (95% CI 0.06–0.83). Scheduled bleeding/spotting occurred in 91.9–94.4% of women over Cycles 1 to 12 and lasted a median of 4–5 days per cycle. The percentage of women with unscheduled bleeding/spotting episodes decreased from 23.5% in Cycle 1 to <16% from Cycle 6 onwards. The most common AEs were headache (7.7%), metrorrhagia (5.5%), vaginal haemorrhage (4.8%) and acne (4.2%). One treatment-related serious AE was reported, a lower extremity venous thromboembolism. One-hundred and forty-one (9.1%) women discontinued study participation because of treatment-related adverse events. Conclusions: E4/DRSP provides effective contraception, a predictable bleeding pattern and a favourable safety profile. Tweetable abstract: A phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile.
We analysed the parsec-scale linear polarization properties of 436 active galactic nuclei (AGNs) based on 15 GHz polarimetric Very Long Baseline Array observations. We present polarization and total intensity images averaged over at least five epochs since 1996 January 19 through 2019 August 4. Stacking improves the image sensitivity down to ∼30 μJy beam−1 and effectively fills out the jet cross-section both in total intensity and linear polarization. It delineates the long-term persistent magnetic field configuration and its regularity by restoring spatial distributions of the electric vector position angle (EVPA) and fractional polarization, respectively. On average, about 10 yr of stacking period is needed to reveal the stable and most-complete polarization distribution of a source. We find that the degree of polarization significantly increases down and across the jet towards its edges, typically manifesting U or W-shaped transverse profiles, suggesting a presence of a large-scale helical magnetic field associated with the outflow. In some AGN jets, mainly BL Lacs, we detect quasi-constant fractional polarization profiles across the jet, accompanied by EVPAs that closely follow the outflow. BL Lacs show higher fractional polarization values in their cores and jets than those in quasars up to hectoparsec de-projected scales, while on larger scales, they become comparable. High-synchrotron-peaked BL Lac jets are found to be less polarized than intermediate and low-synchrotron-peaked BL Lacs. The spatial distribution of the EVPAs in BL Lacs tend to align with the local jet direction, while quasars show an excess of orthogonal polarization orientation.
Abstract In this study activated carbons were produced from the wood of three different wood species (pine, birch, spruce). The resulting activated carbons were characterized in bulk for ash content, carbon content (elemental analyses), specific surface area, and pore size distribution, and at the surface by measuring the autogenerated pH and studying their structure by XPS. All the samples presented high surface areas and appeared to be mesoporous materials (mesopores >80%). The carbons were then used as support for AuPt nanoparticles and tested in the liquid phase oxidation of glycerol (GLY) and in the hydrogenation of levulinic acid (LA), two important chemicals from cellulose-based biomass. The catalytic results showed that the catalyst activity depends on the structural features of carbons: in GLY oxidation the most active catalyst presents the lowest content of carboxylic acid (Birch derived carbon) whereas in LA hydrogenation an higher content of aliphatic structure seems to enhance the stability and therefore the activity of the catalyst (Spruce catalyst). The structure of the carbons does not affect greatly the selectivity of both selected model reactions.
Abstract Objective: To evaluate overall and subgroup efficacy of an estetrol (E4) 15 mg drospirenone (DRSP) 3 mg oral contraceptive in a 24/4-day regimen. Study design: We pooled efficacy outcomes from 2 pivotal phase 3 contraceptive trials with E4/DRSP conducted in the United States/Canada and Europe/Russia. We assessed Pearl Index (PI; pregnancies per 100 participant-years) and 13-cycle life-table pregnancy rates in at-risk cycles (confirmed intercourse and no other contraceptive use) among participants 16 to 35 years. We calculated PI by age and further subcategorization (contraceptive history and body mass index [BMI]). We performed multivariable analysis using Cox regression to assess impact of potential confounding factors. Results: Analyses included 3027 participants, of whom 451 (14.9%) had a BMI ≥30 kg/m2. The pooled PI was 1.52 (95% confidence interval 1.04‐2.16) and the 13-cycle life-table pregnancy rate was 1.28% (0.83%‐1.73%). We calculated unadjusted pooled PI in participants 16 to 25 years and 26 to 35 years of 1.61 (0.94‐2.57) and 1.43 (0.78‐2.40), respectively; in new starters and switchers of 1.88 (1.09‐3.00) and 1.24 (0.68‐2.08), respectively; and by BMI <25 kg/m2, 25 to 29.9 kg/m2, and ≥30 kg/m2 of 1.14 (0.64‐1.88), 2.19 (1.05‐4.03), and 2.27 (0.83‐4.94), respectively. In multivariable analysis, we found associations of prior pregnancy (hazard ratio [HR] 3.61[1.56–8.38]), Black race (HR 4.61[1.97‐10.80]), age 16 to 25 years (HR 2.37[1.09‐5.15]) and compliance <99% of expected pills (HR 4.21[2.04‐8.66]) with conception. Conclusions: E4/DRSP is an effective oral contraceptive overall and across subgroups stratified by age, contraceptive history, and BMI. Other than compliance, predictors of contraceptive failure are nonmodifiable. Implications Statement: Pooled results from two phase 3 trials demonstrate high contraceptive efficacy of the novel estetrol-drospirenone oral contraceptive. Several non–modifiable risk factors, including prior pregnancy, race, and age, are associated with higher pregnancy risk. Additional research is needed to better understand predictors of combined oral contraceptive failure.