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We propose a novel solar thermochemical receiver–reactor array concept for hydrogen production via ceria redox cycling. The receiver–reactor array can improve the solar-to-fuel efficiency by realizing the heat recuperation, reduction, and oxidation processes synchronously. A linear matrix model and a lumped parameter model are developed to predict thermal performance of the new solar thermochemical system. The system thermal performance is characterized by heat recovery effectiveness of solid-phase and solar-to-fuel efficiency. Investigated parameters include reduction temperature, oxygen partial pressure, number of receiver–reactors, concentration ratio, and gas-phase heat recovery effectiveness. For baseline conditions, the solid-phase heat recovery effectiveness and the solar-to-fuel efficiency are found to be 81% and 27%, respectively. For perfect gas-phase heat recovery and a solar concentration ratio of 5,000, the solar-to-fuel efficiency exceeds 40%.
The nearly 33 yr long-term radio light curve obtained with the Metsähovi Radio Observatory 14 m telescope at 37 GHz and the recent 12.7 yr γ-ray light curve of the blazar S5 0716+714 at 0.1-300 GeV from the Fermi Large Area Telescope (Fermi-LAT) were analyzed by using the Lomb-Scargle periodogram and the weighted wavelet Z-transform techniques. In the radio light curve, we discovered a possible quasi-periodic oscillation (QPO) signal of about 352 ± 23 days at a confidence level of ∼3σ. We recalculated the periodicity and its significance in a chosen time range that has higher variability and denser sampling, and then found that the significance had increased to a confidence level of 99.996% (∼4.1σ). This QPO component was further confirmed by fitting a linear autoregressive integrated moving average model to the selected radio light curve. A possible QPO of 960 ± 80 days at a 99.35% level (∼2.7σ) was found in the γ-ray light curve, which generally agrees with the earlier QPO claims of S5 0716+714. This paper discusses possible mechanisms for this potential year-like QPO. One possibility is a pure geometrical scenario with blobs moving helically inside the jet. Another is a supermassive binary black hole involving a gravitational wave-driven regime. In the latter scenario, we derived a milliparsec separation in the binary system that undergoes coalescence within a century due to the emission of low-frequency gravitational waves.
Paxillin is a potential participant in the direct intracellular force transmission which is considered as the foundation of cells sensing and responding to extracellular environment. However, the detection of tension across paxillin has not been achieved due to lacking microsized tools. Herein, a paxillin tension sensor (PaxTs) based on Fluorescence Resonance Energy Transfer (FRET) technique was constructed. PaxTs can be expressed and assembled to FA sites spontaneously to visualize the tension across paxillin with FRET efficiency of ~62.4% in living cells. The tension across paxillin was found to decrease upon shear stress, in which the membrane fluidity and contractility of actin acted as cushions. It is observed that paxillin participates in the pathway of cell membrane-cytoskeleton-FAs for force transmission upon mechanical force in real time visualization, which provides a promising new method to investigate the direct intracellular force transmission in biology and technology.
The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. Here, we utilized an integrative approach combining epidemiology, virus genome sequencing, clinical phenotyping, and experimental validation to locate mutations of clinical importance. We identified 35 recurrent variants, some of which are associated with clinical phenotypes related to severity. One variant, containing a deletion in the Nsp1-coding region (Δ500-532), was found in more than 20% of our sequenced samples and associates with higher RT-PCR cycle thresholds and lower serum IFN-β levels of infected patients. Deletion variants in this locus were found in 37 countries worldwide, and viruses isolated from clinical samples or engineered by reverse genetics with related deletions in Nsp1 also induce lower IFN-β responses in infected Calu-3 cells. Taken together, our virologic surveillance characterizes recurrent genetic diversity and identified mutations in Nsp1 of biological and clinical importance, which collectively may aid molecular diagnostics and drug design.