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Future wireless systems are envisaged to be deployed in various scenarios and across a wide range of frequencies which include below 6 GHz with massive multiple input multiple output (MIMO) configurations and above 6 GHz in the millimeter wave frequency band and extending to the Tera Hertz (THz) band. Successful deployment requires a range of models informed by measurements and extraction of appropriate channel parameters for high data rates and dense deployment. Starting from the deployment scenarios which include traditional cellular deployment, short range and long-range links, and more recent high-speed scenarios including vehicular communication e.g. vehicle to infrastructure and vehicle to vehicle, and high speed train scenarios, on body networks and challenging industrial deployment. Measurements in typical environments are reported for outdoor, indoor, outdoor to indoor and clutter loss with estimated channel parameters such as path loss model coefficients and wideband parameters such as RMS delay spread. Simulations of propagation using ray tracing tools are compared with measurements in various frequency bands. The specifics of propagation in the millimeter wave band including the impact of blockage such as human and vehicular blockage and the impact of precipitation are studied from measurements and simulation. Massive MIMO channel measurements in various frequency bands are assessed and modelled.
In this work, the heat transfer coefficients were determined utilizing an experimental study for cooling a 15B35H boron steel, using aqueous solutions of polyalkylene glycol (PAG) as a cooling fluid. A cooling tank was designed and built to allow the fluid recirculation, where the effect of agitation and the PAG content in a concentration range of 2%-6% vol. were analyzed. The thermal histories of cylindrical probes instrumented with K-type thermocouples were obtained, and the heat transfer coefficients associated with the types of refrigeration were calculated, solving the IHCP. The results show the presence of two maximum surface heat flux denominated q1max for the low-temperature range and q2max for the high-temperature range. Getting higher q1max and low q2max is desirable to avoid distortion and cracking. It was found that 4% PAG exhibits a slight variation of heat flux values in both low and high-temperature regions, regardless of the degree of agitation, maintaining values of about 3 MW·m−2 for q1max and 5.5 MW·m−2 for q2max. In this case, q2max is higher than q1max, leading to higher cooling rates in the martensitic transformation zone, increasing the risk of distortion and cracking. In the cases of 2 y 6% PAG, agitation affects q1max ranging from 2.5 to 6 MW·m−2, and for q2max from 4 to 6 MW·m−2, where q1max is always higher than q2max, providing better conditions for quenching.
Aim Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the relationships of resting leptin and adiponectin with bone parameters and whether high muscular fitness levels affect these relationships in children with overweight or obesity. Methods This cross-sectional study took part from 2014 to 2016 in Granada, Spain. Participants were recruited from University Hospitals, and we also used advertisements in local media and school contacts in the city. Adipokines were analysed in plasma. Muscular fitness was assessed by one repetition maximum in bench and leg press tests. Dual-energy X-ray absorptiometry was used to measure bone parameters. Results We included 84 children (10.0 ± 1.2y; 63% boys) in this analysis. Leptin was negatively associated with lumbar spine bone mineral content (β = −0.162, p = 0.053). No significant interaction was found for muscular fitness. Simple slope estimates suggested that children performing more than 133.3 kg in leg press test ameliorated the negative association between leptin and lumbar spine bone mineral content. Conclusion Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity. A high muscular fitness at the lower body could counteract this association.
We analyze the parsec-scale jet kinematics from 2007 June to 2013January of a sample of γ-ray bright blazars monitored roughlymonthly with the Very Long Baseline Array at 43 GHz. In a total of 1929images, we measure apparent speeds of 252 emission knots in 21 quasars,12 BL Lacertae objects (BLLacs), and 3 radio galaxies, ranging from0.02c to 78c; 21% of the knots are quasi-stationary. Approximatelyone-third of the moving knots execute non-ballistic motions, with thequasars exhibiting acceleration along the jet within 5 pc (projected) ofthe core, and knots in BLLacs tending to decelerate near the core. Usingthe apparent speeds of the components and the timescales of variabilityfrom their light curves, we derive the physical parameters of 120superluminal knots, including variability Doppler factors, Lorentzfactors, and viewing angles. We estimate the half-opening angle of eachjet based on the projected opening angle and scatter of intrinsicviewing angles of knots. We determine characteristic values of thephysical parameters for each jet and active galactic nucleus class basedon the range of values obtained for individual features. We calculatethe intrinsic brightness temperatures of the cores,{T}{{b},{int}}{core}, at all epochs, finding thatthe radio galaxies usually maintain equipartition conditions in thecores, while ∼30% of {T}{{b},{int}}{core}measurements in the quasars and BLLacs deviate from equipartition valuesby a factor >10. This probably occurs during transient eventsconnected with active states. In the Appendix, we briefly describe thebehavior of each blazar during the period analyzed.
The Fermi LAT detected an increase in γ-ray activity of the quasar 0836+710 (z=2.17) in Spring 2011 that culminated in a sharp γ-ray flare at the end of 2011 when the source reached a flux of 2.9×10−6 phot s−1cm−2 at 0.1-200 GeV. We monitor the quasar at optical wavelengths in photometric and polarimetric modes, at millimeter and centimeter wavelengths, and with the VLBA at 43 GHz. The optical brightness of the quasar increased by ~0.5 mag in R band and the degree of polarization oscillated between ~1% and ~6% during the highest γ-ray state, while the position angle of polarization rotated by ~300°. We have identified in the VLBA images a strong, highly polarized component that moves with an apparent speed of ~20 c. The component emerged from the core in the beginning of the γ-ray event and reached a flux maximum at the peak of the γ-ray outburst. We present the results of a correlative analysis of variations at different wavelengths along with the kinematic parameters of the parsec scale jet. We discuss the location of the high γ-ray emission in the relativistic jet, as well as the emission mechanisms responsible for γ-ray production.
Importance Pediatric overweight and obesity are highly prevalent across the world, with implications for poorer cognitive and brain health. Exercise might potentially attenuate these adverse consequences. Objectives To investigate the effects of an exercise program on brain health indicators, including intelligence, executive function, academic performance, and brain outcomes, among children with overweight or obesity and to explore potential mediators and moderators of the main effects of exercise. Design, Setting, and Participants All preexercise and postexercise data for this 20-week randomized clinical trial of 109 children aged 8 to 11 years with overweight or obesity were collected from November 21, 2014, to June 30, 2016, with neuroimaging data processing and analyses conducted between June 1, 2017, and December 20, 2021. All 109 children were included in the intention-to-treat analyses; 90 children (82.6%) completed the postexercise evaluation and attended 70% or more of the recommended exercise sessions and were included in per-protocol analyses. Interventions All participants received lifestyle recommendations. The control group continued their usual routines, whereas the exercise group attended a minimum of 3 supervised 90-minute sessions per week in an out-of-school setting. Main Outcomes and Measures Intelligence, executive function (cognitive flexibility, inhibition, and working memory), and academic performance were assessed with standardized tests, and hippocampal volume was measured with magnetic resonance imaging. Results The 109 participants included 45 girls (41.3%); participants had a mean (SD) body mass index of 26.8 (3.6) and a mean (SD) age of 10.0 (1.1) years at baseline. In per-protocol analyses, the exercise intervention improved crystallized intelligence, with the exercise group improving from before exercise to after exercise (mean z score, 0.62 [95% CI, 0.44-0.80]) compared with the control group (mean z score, –0.10 [95% CI, –0.28 to 0.09]; difference between groups, 0.72 SDs [95% CI, 0.46-0.97]; P < .001). Total intelligence also improved significantly more in the exercise group (mean z score, 0.69 [95% CI, 0.48-0.89]) than in the control group (mean z score, 0.07 [95% CI, –0.14 to 0.28]; difference between groups, 0.62 SDs [95% CI, 0.31-0.91]; P < .001). Exercise also positively affected a composite score of cognitive flexibility (mean z score: exercise group, 0.25 [95% CI, 0.05-0.44]; control group, –0.17 [95% CI, –0.39 to 0.04]; difference between groups, 0.42 SDs [95% CI, 0.13-0.71]; P = .005). These main effects were consistent in intention-to-treat analyses and after multiple-testing correction. There was a positive, small-magnitude effect of exercise on total academic performance (mean z score: exercise group, 0.31 [95% CI, 0.18-0.44]; control group, 0.10 [95% CI, –0.04 to 0.24]; difference between groups, 0.21 SDs [95% CI, 0.01-0.40]; P = .03), which was partially mediated by cognitive flexibility. Inhibition, working memory, hippocampal volume, and other brain magnetic resonance imaging outcomes studied were not affected by the exercise program. The intervention increased cardiorespiratory fitness performance as indicated by longer treadmill time to exhaustion (mean z score: exercise group, 0.54 [95% CI, 0.27-0.82]; control group, 0.13 [95% CI, –0.16 to 0.41]; difference between groups, 0.42 SDs [95% CI, 0.01-0.82]; P = .04), and these changes in fitness mediated some of the effects (small percentage of mediation [approximately 10%-20%]). The effects of exercise were overall consistent across the moderators tested, except for larger improvements in intelligence among boys compared with girls. Conclusions and Relevance In this randomized clinical trial, exercise positively affected intelligence and cognitive flexibility during development among children with overweight or obesity. However, the structural and functional brain changes responsible for these improvements were not identified. Trial Registration ClinicalTrials.gov Identifier: NCT02295072
Alzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65–80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved.
We present multi-wavelength studies of the radio galaxy 3C 120 and the blazar CTA 102 during unprecedented γ-ray flares for both sources. In both studies the analysis of γ-ray data has been compared with a series of 43 GHz VLBA images from the VLBA-BU-BLAZAR program, providing the necessary spatial resolution to probe the parsec scale jet evolution during the high energy events. To extend the radio dataset for 3C 120 we also used 15 GHz VLBA data from the MOJAVE sample. These two objects which represent very different classes of AGN, have similar properties during the γ-ray events. The γ-ray flares are associated with the passage of a new superluminal component through the mm VLBI core, but not all ejections of new components lead to γ-ray events. In both sources γ-ray events occurred only when the new components are moving in a direction closer to our line of sight. We locate the γ-ray dissipation zone a short distance from the radio core but outside of the broad line region, suggesting synchrotron self-Compton scattering as the probable mechanism for the γ-ray production.