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Abstract In the present work, we report the imaging of Au nanostars nanoparticles (AuNSt) and their multifunctional applications in biomedical research and theranostics applications. Their optical and spectroscopic properties are considered for the multimodal imaging purpose. The AuNSt are prepared by the seed-meditated method and characterized for use as an agent for bio-imaging. To demonstrate imaging with AuNSt, penetration and localization in different biological models such as cancer cell culture (A549 lung carcinoma cell), 3D tissue model (multicellular tumor spheroid on the base of human oral squamous carcinoma cell, SAS) and murine skin tissue are studied. AuNSt were visualized using fluorescence lifetime imaging (FLIM) at two-photon excitation with a pulse duration 140 fs, repetition rate 80 MHz and 780 nm wavelength femtosecond laser. Strong emission of AuNSt at two-photon excitation in the near infrared range and fluorescence lifetime less than 0.5 ns were observed. It allows using AuNSt as a fluorescent marker at two-photon fluorescence microscopy and lifetime imaging (FLIM). It was shown that AuNSt can be observed inside a thick sample (tissue and its model). This is the first demonstration using AuNSt as an imaging agent for FLIM at two-photon excitation in biosystems. Increased scattering of near-infrared light upon excitation of AuNSt surface plasmon oscillation was also observed and rendered using a possible contrast agent for optical coherence tomography (OCT). AuNSt detection in a biological system using FLIM is compared with OCT on the model of AuNSt penetrating into animal skin. The AuNSt application for multimodal imaging is discussed.
Abstract In wideband joint communications and sensing (JCAS) systems, the waveforms are often designed and optimized over the entire bandwidth. This significantly limits the degrees of freedom in beamforming and causes severe communications performance loss, especially under a strict radar sensing constraint. In this work, we consider a downlink of a wideband multiuser (MU) multiple-input multiple-output (MIMO) system. We propose a subcarrier allocation strategy incorporated in an efficient JCAS design to improve the communications–sensing performance tradeoff of the system. The main idea is to employ a subset of subcarriers for radar sensing while enabling communications over the entire bandwidth. This creates dedicated subcarriers for communications without any interference from the radar function, whose sensing accuracy can still be guaranteed through strict design constraints. To realize the idea, we formulate the sum rate maximization problem and propose a three-step solution based on successive convex approximation and Riemannian manifold optimization. We further propose efficient initialization methods to reduce complexity and improve the convergence of the employed optimization schemes. Our simulation results for a 32 × 4 MU-MIMO system show that the proposed scheme offers 70% improvement in the system sum rate while guaranteeing the same radar beampattern mean square error and requiring less radio frequency chains compared with the conventional JCAS design over the entire bandwidth.
Abstract Engineering the optical bandgaps of classic ferroelectrics from the typical ultraviolet range down to the visible range is an emerging methodology of developing the next-generation optoelectric and opto-ferroelectric devices including ferroelectric solar cells, light-driven transistors and modulators, and multi-sensors/energy harvesters. Recently, a material interface comprised of a pseudo-morphotropic phase boundary between the tungsten bronze and perovskite phases of the KNBNNO [(K,Na,Ba)x(Ni,Nb)yOz] has been reported to be an effective approach for bandgap engineering while retaining excellent ferroelectricity and piezoelectricity of the perovskite-phased KNBNNO. However, this approach requires the compositions of the materials to be determined at the synthesis stage, leaving little room for any further modification of the microstructure and functional properties at the post-processing stage. This paper presents a post-processing method, that is, atmospheric annealing in N2 and O2, to grow the necessary tungsten bronze phase out of the perovskite phase in the KNBNNO. This method is advantageous over the previously reported because it enables to grow the tungsten bronze–perovskite interface region independent of the initial composition. The distinctive electrical properties and the giant tunability of photoconductivity of the tungsten bronze phase, the perovskite phase, and the interface are characterized in detail in this paper, supporting the exploitation of fabricating opto-ferroelectric devices using the reported method which is compatible and comparable with some of the post-processing methods applied in the silicon industry.
Abstract Hybrid beamforming (HBF) is a key enabler for millimeter-wave (mmWave) communications systems, but HBF optimizations are often non-convex and of large dimension. In this paper, we propose an efficient deep unfolding-based HBF scheme, referred to as ManNet-HBF, that approximately maximizes the system spectral efficiency (SE). It first factorizes the optimal digital beamformer into analog and digital terms, and then reformulates the resultant matrix factorization problem as an equivalent maximum-likelihood problem, whose analog beamforming solution is vectorized and estimated efficiently with ManNet, a lightweight deep neural network. Numerical results verify that the proposed ManNet-HBF approach has near-optimal performance comparable to or better than conventional model-based counterparts, with very low complexity and a fast run time. For example, in a simulation with 128 transmit antennas, it attains 98.62% the SE of the Riemannian manifold scheme but 13250 times faster.
Abstract Recent development of nanoparticles bio-medical applications is determined by perspectives of their use for multimodal bio-imaging and sensing. Informative and noninvasive optical-spectroscopic methods are designed for the detection and analysis of the NP interaction with target biological systems. Presented work is focused on study of nanoparticles interaction with biological tissues combining complimentary methods to obtain versatile optical-spectroscopic information.
Instabilities are common phenomena frequently observed in nature, sometimes leading to unexpected catastrophes and disasters in seemingly normal conditions. One prominent form of instability in a distributed system is its response to a harmonic modulation. Such instability has special names in various branches of physics and is generally known as modulation instability (MI). The MI leads to a growth-decay cycle of unstable waves and is therefore related to Fermi-Pasta-Ulam (FPU) recurrence since breather solutions of the nonlinear Schrödinger equation (NLSE) are known to accurately describe growth and decay of modulationally unstable waves in conservative systems. Here, we report theoretical, numerical and experimental evidence of the effect of dissipation on FPU cycles in a super wave tank, namely their shift in a determined order. In showing that ideal NLSE breather solutions can describe such dissipative nonlinear dynamics, our results may impact the interpretation of a wide range of new physics scenarios.
Abstract There are increasing demands for developing fluorine-free mold fluxes for continuous casting of steel. When removing fluorine from mold flux composition, it is necessary to replace it with oxides, which must maintain the technological parameters, related to viscosity, melting characteristics, and crystallization behavior. For industrial developments in the CaO–SiO2–Na2O–Al2O3–TiO2–B2O3–MgO (with basicity = 1, Al2O3 = 7%, TiO2 = 5%, B2O3 = 3%, MgO = 2%) slag system, it is necessary to know the effect of Na2O concentration regarding crystallization kinetics. This is especially important for fluorine-free mold fluxes for peritectic steel slab casting. In this work, the crystals’ precipitation sequence for this system during cooling was determined, combining Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), and Scanning Electron Microscopy (SEM). The Friedman differential isoconversional method was applied for determining the effective activation energy for non-isothermal crystallization, since it gives relevant information without knowing the form of the kinetic equation. A modified Avrami model was used to calculate the n values; it was found that they are near 2.5, for all analyzed samples, which means that it is related to the crystallization mode diffusion controlled, with constant nucleation rate and three-dimensional growth. This agrees with the SEM micrographs, where dendritic structure is observed for all crystalline samples. Additionally, structural information got from Raman spectroscopy, for the samples in vitreous state, was used to interpret crystallization tendency, i.e., the fact that crystallization was enhanced by increasing Na2O content, due to slag depolymerization. Moreover, computational thermodynamics was used to analyze mold fluxes crystallization behavior.
Abstract Rapid (<1 s) intensity modulation of pulsating auroras is caused by successive chorus elements as a response to wave‐particle interactions in the magnetosphere. Here we found that a pulsating auroral patch responds to the time spacing for successive chorus elements and possibly to chorus subpacket structures with a time scale of tens of milliseconds. These responses were identified from coordinated Arase satellite and ground (Gakona, Alaska) observations with a high‐speed auroral imager (100 Hz). The temporal variations of auroral intensity in a few‐hertz frequency range exhibited a spatial concentration at the lower‐latitude edge of the auroral patch. The spatial evolution of the auroral patch showed repeated expansion/contraction with tens of kilometer scales in the ionosphere, which could be spatial behaviors in the wave‐particle interactions. These observations indicate that chorus elements evolve coherently within the auroral patch, which is approximately 900 km in the radial and longitudinal directions at the magnetic equator.
Abstract It is well known that auroral patterns at the substorm recovery phase are characterized by diffuse or patch structures with intensity pulsation. According to satellite measurements and simulation studies, the precipitating electrons associated with these aurorae can reach or exceed energies of a few hundreds of keV through resonant wave‐particle interactions in the magnetosphere. However, because of difficulty of simultaneous measurements, the dependency of energetic electron precipitation (EEP) on auroral morphological changes in the mesoscale has not been investigated to date. In order to study this dependency, we have analyzed data from the European Incoherent Scatter (EISCAT) radar, the Kilpisjärvi Atmospheric Imaging Receiver Array (KAIRA) riometer, collocated cameras, ground‐based magnetometers, the Van Allen Probe satellites, Polar Operational Environmental Satellites (POES), and the Antarctic‐Arctic Radiation‐belt (Dynamic) Deposition‐VLF Atmospheric Research Konsortium (AARDDVARK). Here we undertake a detailed examination of two case studies. The selected two events suggest that the highest energy of EEP on those days occurred with auroral patch formation from postmidnight to dawn, coinciding with the substorm onset at local midnight. Measurements of the EISCAT radar showed ionization as low as 65 km altitude, corresponding to EEP with energies of about 500 keV.
Background: Heavy-flavor modification in relativistic p ( d ) + A collisions are sensitive to different kinds of strong-interaction physics ranging from modifications of the nuclear wave function to initial- and final-state energy loss. Modifications to single heavy-flavor particles and their decay leptons at midrapidity and forward rapidity are well established at the Relativistic Heavy Ion Collider (RHIC). Purpose: This paper presents measurements of azimuthal correlations of electron-muon pairs produced from heavy-flavor decays, primarily c ̄ c ,in √ s NN = 200 GeV p + p and d + Au collision using the PHENIX detector at RHIC. The electrons are measured at midrapidity while the muons in the pair are measured at forward rapidity, defined as the direction of the deuteron beam, in order to utilize the deuteron to probe low- x partons in the gold nucleus. Methods: This analysis uses the central spectrometer arms for electron identification and forward spectrometer arms for muon identification. Azimuthal correlations are built in all sign combinations for e - μ pairs. Subtracting the like-sign yield from the unlike-sign yield removes the correlations from light flavor decays and conversions. Results: Comparing the p + p results with several different Monte Carlo event generators, we find the results are consistent with a total charm cross section σ c ̄ c = 538 ± 46 (stat) ± 197 (data syst) ± 174 (model syst) μ b. These generators also indicate that the back-to-back peak at φ = π is dominantly from the leading-order contributions (gluon fusion), while higher-order processes (flavor excitation and gluon splitting) contribute to the yield at all φ . We observe a suppression in the pair yield per collision in d + Au. We find the pair yield suppression factor for 2 . 7 < φ< 3 . 2radis J dA = 0 . 433 ± 0 . 087 (stat) ± 0.135 (syst). Conclusions: The e - μ pairs result from partons at x Au ∼ 10 − 2 at Q 2 = 10 GeV /c 2 at the edge of the shadowing region. The pair suppression indicates modification to c ̄ c pairs for these kinematics in the cold nuclear medium at RHIC.
[Introduction] Measurements of transverse-single-spin asymmetries ( A N )in p þ p collisions at ffiffiffi s p ¼ 62 . 4 and 200 GeV with the PHENIX detector at the Relativistic Heavy Ion Collider are presented. At midrapidity, A N is measured for neutral pion and eta mesons reconstructed from diphoton decay, and, at forward rapidities, neutral pions are measured using both diphotons and electromagnetic clusters. The neutral-pion measurement of A N at midrapidity is consistent with zero with uncertainties a factor of 20 smaller than previous publications, which will lead to improved constraints on the gluon Sivers function. At higher rapidities, where the valence quark distributions are probed, the data exhibit sizable asymmetries. In comparison with previous measurements in this kinematic region, the new data extend the kinematic coverage in ffiffiffi s p and p T , and it is found that the asymmetries depend only weakly on ffiffiffi s p . The origin of the forward A N is presently not understood quantitatively. The extended reach to higher p T probes the transition between transverse momentum dependent effects at low p T and multiparton dynamics at high p T .
We analysed the parsec-scale linear polarization properties of 436 active galactic nuclei (AGNs) based on 15 GHz polarimetric Very Long Baseline Array observations. We present polarization and total intensity images averaged over at least five epochs since 1996 January 19 through 2019 August 4. Stacking improves the image sensitivity down to ∼30 μJy beam−1 and effectively fills out the jet cross-section both in total intensity and linear polarization. It delineates the long-term persistent magnetic field configuration and its regularity by restoring spatial distributions of the electric vector position angle (EVPA) and fractional polarization, respectively. On average, about 10 yr of stacking period is needed to reveal the stable and most-complete polarization distribution of a source. We find that the degree of polarization significantly increases down and across the jet towards its edges, typically manifesting U or W-shaped transverse profiles, suggesting a presence of a large-scale helical magnetic field associated with the outflow. In some AGN jets, mainly BL Lacs, we detect quasi-constant fractional polarization profiles across the jet, accompanied by EVPAs that closely follow the outflow. BL Lacs show higher fractional polarization values in their cores and jets than those in quasars up to hectoparsec de-projected scales, while on larger scales, they become comparable. High-synchrotron-peaked BL Lac jets are found to be less polarized than intermediate and low-synchrotron-peaked BL Lacs. The spatial distribution of the EVPAs in BL Lacs tend to align with the local jet direction, while quasars show an excess of orthogonal polarization orientation.
Abstract In this study, we aimed to determine if pretreatment low-density lipoprotein (LDL) levels and aortic stenosis (AS) severity alter the efficacy of lipid-lowering therapy on reducing aortic valve replacement (AVR). We used 1,687 patients with asymptomatic mild-to-moderate AS, who were randomly assigned (1:1) to 40/10 mg simvastatin/ezetimibe combination versus. placebo in the simvastatin and ezetimibe in aortic stenosis (SEAS) trial. Pretreatment LDL levels (>4 mmol/L) and peak aortic jet velocity (3 m/s) were used to partition study participants into 4 groups, which were followed for a primary endpoint of AVR. Cox regression with tests for interaction was used to study the effect of randomized treatment in each subgroup. During a median follow-up of 4.3 years (IQR 4.2 to 4.7 years; total 7,396 patient-years of follow-up), 478 (28%) patients underwent AVR and 146 (9%) died. A significant risk dependency was detected between simvastatin/ezetimibe combination, LDL levels and mild versus moderate AS on rates of AVR (p = 0.01 for interaction). In stratified analyses, randomized treatment, therefore, reduced the rate of AVR in patients with LDL levels >4 mmol and mild AS at baseline (HR 0.4; 95% CI: 0.2 to 0.9). There was no detectable effect of randomized treatment on the need for AVR in the 3 other participants subgroups. We conclude, that in a secondary analysis from a prospective randomized clinical trial, treatment with simvastatin/ezetimibe combination reduced the need for AVR in a subset of patients with mild AS and high pretreatment LDL levels (Unique identifier on clinicaltrials.gov: NCT00092677).
Abstract The association between raised blood pressure and increased risk of subsequent cognitive decline is well known. Left ventricular hypertrophy (LVH), as a marker of hypertensive target organ damage, may help identify those at risk of cognitive decline. We assessed whether LVH was associated with subsequent cognitive decline or dementia in hypertensive participants aged ≥80 years in the randomized, placebo-controlled Hypertension in the Very Elderly Trial. LVH was assessed using 12-lead electrocardiography (ECG) based on the Cornell Product (CP-LVH), Sokolow-Lyon (SL-LVH), and Cornell Voltage (CV-LVH) criteria. The Mini-Mental State Examination (MMSE) was used to assess cognitive function at baseline and annually. A fall in MMSE to <24 or an annual fall of >3 points were defined as cognitive decline and triggered dementia screening (Diagnostic Statistical Manual IV). Death was defined as a competing event. Fine-Gray regression models were used to examine the relationship between baseline LVH and cognitive outcomes. There were 2645 in the analytical sample, including 201 (7.6%) with CP-LVH, 225 (8.5%) SL-LVH and 251 (9.5%) CV-LVH. CP-LVH was associated with increased risk of cognitive decline, subdistribution hazard ratio (sHR)1.3 (95% confidence interval (CI) 1.01–1.67) in multivariate analyses. SL-LVH and CV-LVH were not associated with cognitive decline (sHR1.06 (95% CI 0.82–1.37) and sHR1.13 (95% CI 0.89–1.43), respectively). LVH was not associated with dementia. LVH may be related to subsequent cognitive decline, but evidence was inconsistent depending on ECG criterion and there were no associations with incident dementia. Additional work is needed to understand the relationships between blood pressure, LVH assessment and cognition.
We evaluated the accuracy of biology informed genomic prediction for dry matter intake in 2,162 Dutch Holstein cows. Sequence variants were selected from meta-analyses including GWAS summary statistics for QTL and metabolomic QTL in several dairy and crossbred beef populations. Selected variants were prioritized in GBLUP models in a five-fold cross-validation. The accuracies were compared to genomic prediction based on routine 50k genotype data. The average accuracy for the 50k scenario was 0.683. Adding selected sequence variants in the GBLUP model did not improve the accuracies for dry matter intake. Next steps will include testing Bayesian variable selection methods to prioritize variants in genomic prediction for dry matter intake.
Using stacking of images obtained at different epochs, we studied the variability properties of linear polarization of active galactic nucleus (AGN) jets on parsec-scales. Our sample is drawn from the MOJAVE programme, and consists of 436 AGNs manifesting core-jet morphology and having at least five VLBA observing epochs at 15 GHz from 1996 January through 2019 August, with some additional archival VLBA data reduced by us. We employed a stacking procedure and constructed maps of (i) standard deviation of fractional polarization and electric vector position angle (EVPA) over epochs as the measure of variability and (ii) median polarization degree to quantify typical values in time. The distributions of these values along and across the jet were analysed for the whole sample for the first time. We found that core EVPA variability is typically higher than that of the jet, presumably due to component blending and outflow bends in the core. The BL Lacertae object cores have lower EVPA variability, compared to that of quasars, possibly due to lower Faraday rotation measure, suggesting a stronger ordered magnetic field component. The EVPA becomes more stable down the jet. Most of the sources showing this trend have a time coverage of more than 12 yr and at least 15 epochs. The possible cause could be the increase of stability in the magnetic field direction, reflecting an increase in the fraction of the magnetic field that is ordered. There are no significant optical-class-dependent or spectral-class-dependent relations in the EVPA variability properties in AGN jets.
Abstract Context: Polycystic ovary syndrome (PCOS) is characterized by ovulatory dysfunction and hyperandrogenism and can be associated with cardiometabolic dysfunction, but it remains unclear which of these features are inciting causes and which are secondary consequences. Objective: To determine whether ovarian function is necessary for genetic risk factors for PCOS to produce nonreproductive phenotypes. Design, Setting, and Participants: Cohort of 176 360 men in the UK Biobank and replication cohort of 37 348 men in the Estonian Biobank. Main Outcome Measures: We calculated individual PCOS polygenic risk scores (PRS), tested for association of these PRS with PCOS-related phenotypes using linear and logistic regression and performed mediation analysis. Results: For every 1 SD increase in the PCOS PRS, men had increased odds of obesity (odds ratio [OR]: 1.09; 95% CI, 1.08-1.10; P = 1 × 10-49), type 2 diabetes mellitus (T2DM) (OR: 1.08; 95% CI, 1.05-1.10; P = 3 × 10-12), coronary artery disease (CAD) (OR: 1.03; 95% CI, 1.01-1.04; P = 0.0029), and marked androgenic alopecia (OR: 1.03; 95% CI, 1.02-1.05; P = 3 × 10-5). Body mass index (BMI), hemoglobin A1c, triglycerides, and free androgen index increased as the PRS increased, whereas high-density lipoprotein cholesterol and SHBG decreased (all P < .0001). The association between the PRS and CAD appeared to be completely mediated by BMI, whereas the associations with T2DM and marked androgenic alopecia appeared to be partially mediated by BMI. Conclusions: Genetic risk factors for PCOS have phenotypic consequences in men, indicating that they can act independently of ovarian function. Thus, PCOS in women may not always be a primary disorder of the ovaries.
Abstract There has been increasing evidence for pitch angle scattering of relativistic electrons by electromagnetic ion cyclotron (EMIC) waves. Theoretical studies have predicted that the loss time scale of MeV electrons by EMIC waves can be very fast, suggesting that MeV electron fluxes rapidly decrease in association with the EMIC wave activity. This study reports on a unique event of MeV electron loss induced by EMIC waves based on Arase, Van Allen Probes, and ground‐based network observations. Arase observed a signature of MeV electron loss by EMIC waves, and the satellite and ground‐based observations constrained spatial‐temporal variations of the EMIC wave activity during the loss event. Multisatellite observation of MeV electron fluxes showed that ~2.5‐MeV electron fluxes substantially decreased within a few tens of minutes where the EMIC waves were present. The present study provides an observational estimate of the loss time scale of MeV electrons by EMIC waves.
We examine the evolution of the water production of comet 67P/Churyumov-Gerasimenko during the Rosetta mission (2014 June-2016 May) based on in situ and remote sensing measurements made by Rosetta instruments, Earth-based telescopes and through the development of an empirical coma model. The derivation of the empirical model is described and the model is then applied to detrend spacecraft position effects from the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) data. The inter-comparison of the instrument data sets shows a high level of consistency and provides insights into the water and dust production. We examine different phases of the orbit, including the early mission (beyond 3.5 au) where the ROSINA water production does not show the expected increase with decreasing heliocentric distance. A second important phase is the period around the inbound equinox, where the peak water production makes a dramatic transition from northern to southern latitudes. During this transition, the water distribution is complex, but is driven by rotation and active areas in the north and south. Finally, we consider the perihelion period, where there may be evidence of time dependence in the water production rate. The peak water production, as measured by ROSINA, occurs 18-22 d after perihelion at 3.5 +/- 0.5 x 10(28) water molecules s(-1). We show that the water production is highly correlated with ground-based dust measurements, possibly indicating that several dust parameters are constant during the observed period. Using estimates of the dust/gas ratio, we use our measured water production rate to calculate a uniform surface loss of 2-4 m during the current perihelion passage.
Résumé Il y a une vingtaine d’années, des dents de mammouths ont été retrouvées dans les déblais de la décharge de la commune d’Aubais (Gard, Sud-Est de la France). Des opérations de fouille de sauvetage, de tri et de tamisage ont par la suite été menées et ont permis d’identifier la présence de 19 taxons de vertébrés continentaux. Les carnivores dominent (n=10), suivis par les herbivores (n=5), les oiseaux (n=1) et les léporidés (n=2) dont les restes sont les plus abondants. Aucun reste de micromammifères n’a en revanche été retrouvé. Les observations sédimentologiques croisées aux données géologiques locales permettent d’affirmer l’homogénéité de la faune piégée dans une ancienne doline creusée dans des niveaux burdigaliens. Les restes osseux étaient à l’origine en bon état de conservation mais ont été fragmentés lors de leur extraction par des engins de terrassement (fracturation et griffures d’engins). Le type d’extraction du sédiment à l’origine de ces déblais n’a pas permis de procéder à une étude taphonomique. Les différentes études fauniques permettent de positionner chronologiquement le gisement au cours du stade isotopique 6. Aucune trace d’activités humaines et carnivores n’a été détectée et la faune de la décharge d’Aubais permet de mieux comprendre l’environnement dans lequel évoluaient les groupes humains de la région à fin du Pléistocène moyen.
Abstract Ultra-reliable low latency communications (URLLC) service class introduced in Fifth Generation (5G) New Radio (NR) caters to mission-critical applications with stringent quality of service requirements. Meeting such demanding design goals require a paradigm shift in resource management procedures. Conventional reactive schemes need to be replaced by novel and proactive resource management schemes that can efficiently meet such demanding design targets. In this paper, we propose a novel location-aware transmission rate adjustment scheduling procedure for URLLC networks based on a predictive interference management scheme. Prior to scheduling, a geographical relocation of some of the receivers, which cannot overcome a minimum reliability/outage requirement set by physical layer, is enforced if the corresponding long term channel and interference statistics fail to meet a proposed criteria. Extensive system level simulations show that the proposed relocation and interference prediction based scheduling method meets the reliability constraint and enhances utilization factor of the scalable URLLC network resource significantly. The proposed scheme demonstrates around an order of magnitude lower outage probability compared to a baseline conventional scheme, while having a higher resource efficiency.
Abstract The aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. The participants consisted of 71 premenopausal Finnish women (aged 19–49 years). Gut microbiota were analyzed using flow cytometry, 16S rRNA gene hybridization and DNA-staining. Maximum oxygen uptake (VO2max) was assessed by respiratory gas analyzer and body composition by Bioimpdance. We found that participants with low VO2max had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than the high VO2max group (p < 0.05 for all). VO2max was inversely associated with EreC (r = −0.309, p = 0.01) but not with other bacteria. VO2max also negatively correlated with fat% (r = −0.755, p < 0.001), triglycerides (r = −0.274, p = 0.021) and leptin (r = −0.574, p < 0.001). By contrast, EreC was positively associated with fat% (r = 0.382, p = 0.002), dietary fat intake (r = 0.258, p = 0.034), triglycerides (r = 0.390, p = 0.002) and leptin (r = 0.424, p = 0.001), but negatively with carbohydrate intake (r = −0.252, p = 0.034) and HDL (r = −0.26, p = 0.028). After adjusting for age and dietary intake, all the significant associations remained. However, after adjusting for fat%, the associations between VO2max and EreC disappeared. Our results suggest that cardiorespiratory fitness is associated with gut microbiota composition, independent of age and carbohydrate or fat intake. The association between VO2max and EreC, however, appears to be mediated by body fatness.
Abstract: Results are presented from data recorded in 2009 by the PHENIX experiment at the Relativistic Heavy Ion Collider for the double-longitudinal spin asymmetry, A LL , for π 0 and η production in ffiffiffi s p ¼ 200 GeV polarized p þ p collisions. Comparison of the π 0 results with different theory expectations based on fits of other published data showed a preference for small positive values of gluon polarization, Δ G , in the proton in the probed Bjorken x range. The effect of adding the new 2009 π 0 data to a recent global analysis of polarized scattering data is also shown, resulting in a best fit value Δ G ½ 0 . 05 ; 0 . 2 DSSV ¼ 0 . 06 þ 0 . 11 − 0 . 15 in the range 0 . 05 <x< 0 . 2 , with the uncertainty at Δ χ 2 ¼ 9 when considering only statistical experimental uncertainties. Shifting the PHENIX data points by their systematic uncertainty leads to a variation of the best-fit value of Δ G ½ 0 . 05 ; 0 . 2 DSSV between 0.02 and 0.12, demonstrating the need for full treatment of the experimental systematic uncertainties in future global analyses.
Abstract The Alpha Magnetic Spectrometer (AMS) is a precision particle physics detector on the International Space Station (ISS) conducting a unique, long-duration mission of fundamental physics research in space. The physics objectives include the precise studies of the origin of dark matter, antimatter, and cosmic rays as well as the exploration of new phenomena. Following a 16-year period of construction and testing, and a precursor flight on the Space Shuttle, AMS was installed on the ISS on May 19, 2011. In this report we present results based on 120 billion charged cosmic ray events up to multi-TeV energies. This includes the fluxes of positrons, electrons, antiprotons, protons, and nuclei. These results provide unexpected information, which cannot be explained by the current theoretical models. The accuracy and characteristics of the data, simultaneously from many different types of cosmic rays, provide unique input to the understanding of origins, acceleration, and propagation of cosmic rays.
Abstract Knee osteoarthritis (OA) is a heterogeneous disease associated with substantial effects on quality of life, and its clinical management is difficult. Among the several available guidelines for the management of knee OA, those from OARSI and ESCEO were updated in 2019. Here, we examine the similarities and differences between these two guidelines and provide a narrative to help guide health-care providers through the complexities of non-surgical management of knee OA. OARSI and ESCEO both recommend education, structured exercise and weight loss as core treatments, topical NSAIDs as first-line treatments and oral NSAIDs and intra-articular injections for persistent pain. Low-dose, short-term acetaminophen, pharmaceutical grade glucosamine and chondroitin sulfate are recommended by ESCEO whereas OARSI strongly recommends against their use (including all glucosamine and chondroitin formulations). Despite this difference, the two guidelines are consistent in the majority of their recommendations and provide useful treatment recommendations for individuals with OA and health-care providers.
Abstract Context: Radio continuum surveys of the Galactic plane are an excellent way to identify different source populations such as planetary nebulae, H II regions, and radio stars and characterize their statistical properties. The Global View of Star Formation in the Milky Way (GLOSTAR) survey will study the star formation in the Galactic plane between −2° < l < 85° and |b| < 1° with unprecedented sensitivity in both flux density (∼40 μJy beam−1) and range ofangular scales (∼1′′.5 to the largest radio structures in the Galaxy). Aims: In this paper we present the first results obtained from a radio continuum map of a 16-square-degree-sized region of the Galactic plane centered on l = 32° and b = 0° (28° < l < 36° and |b| <1°). This map has a resolution of 18′′ and a sensitivity of ∼60−150 μJy beam−1. Methods: We present data acquired in 40 h of observations with the VLA in D-configuration. Two 1 GHz wide sub-bands were observed simultaneously and they were centered at 4.7 and 6.9 GHz. These data were calibrated and imaged using the Obit software package. The source extraction was performed using the BLOBCAT software package and verified through a combination of visual inspection and cross-matching with other radio and mid-infrared surveys. Results: The final catalog consists of 1575 discrete radio sources and 27 large scale structures (including W43 and W44). By cross-matching with other catalogs and calculating the spectral indices (S(ν) ∝ να), we have classified 231 continuum sources as H II regions, 37 as ionization fronts, and 46 as planetary nebulae. The longitude and latitude distribution and negative spectral indices are all consistent with the vast majority of the unclassified sources being extragalactic background sources. Conclusions: We present a catalog of 1575 radio continuum sources and discuss their physical properties, emission nature, and relation to previously reported data. These first GLOSTAR results have increased the number of reliable H II regions in this part of the Galaxy by a factor of four.
One of the primary objectives of the Rosetta Plasma Consortium, a suite of five plasma instruments on-board the Rosetta spacecraft, is to observe the formation and evolution of plasma interaction regions at the comet 67P/Churyumov-Gerasimenko (67P/CG). Observations made between 2015 April and 2016 February show that solar wind-cometary plasma interaction boundaries and regions formed around 2015 mid-April and lasted through early 2016 January. At least two regions were observed, separated by an ion-neutral collisionopause boundary. The inner region was located on the nucleus side of the boundary and was characterized by low-energy water-group ions, reduced magnetic field pileup and enhanced electron densities. The outer region was located outside of the boundary and was characterized by reduced electron densities, water-group ions that are accelerated to energies above 100 eV and enhanced magnetic field pileup compared to the inner region. The boundary discussed here is outside of the diamagnetic cavity and shows characteristics similar to observations made on-board the Giotto spacecraft in the ion pileup region at 1P/Halley. We find that the boundary is likely to be related to ion-neutral collisions and that its location is influenced by variability in the neutral density and the solar wind dynamic pressure.
Abstract We report the observation of new properties of primary cosmic rays, neon (Ne), magnesium (Mg), and silicon (Si), measured in the rigidity range 2.15 GV to 3.0 TV with 1.8×106 Ne, 2.2×106 Mg, and 1.6×106 Si nuclei collected by the Alpha Magnetic Spectrometer experiment on the International Space Station. The Ne and Mg spectra have identical rigidity dependence above 3.65 GV. The three spectra have identical rigidity dependence above 86.5 GV, deviate from a single power law above 200 GV, and harden in an identical way. Unexpectedly, above 86.5 GV the rigidity dependence of primary cosmic rays Ne, Mg, and Si spectra is different from the rigidity dependence of primary cosmic rays He, C, and O. This shows that the Ne, Mg, and Si and He, C, and O are two different classes of primary cosmic rays.
BACKGROUND: The basidiomycete Phanerochaete carnosa is a white-rot species that has been mainly isolated from coniferous softwood. Given the particular recalcitrance of softwoods to bioconversion, we conducted a comparative transcriptomic analysis of P. carnosa following growth on wood powder from one softwood (spruce; Picea glauca) and one hardwood (aspen; Populus tremuloides). P. carnosa was grown on each substrate for over one month, and mycelia were harvested at five time points for total RNA sequencing. Residual wood powder was also analyzed for total sugar and lignin composition. RESULTS: Following a slightly longer lag phase of growth on spruce, radial expansion of the P. carnosa colony was similar on spruce and aspen. Consistent with this observation, the pattern of gene expression by P. carnosa on each substrate converged following the initial adaptation. On both substrates, highest transcript abundances were attributed to genes predicted to encode manganese peroxidases (MnP), along with auxiliary activities from carbohydrate-active enzyme (CAZy) families AA3 and AA5. In addition, a lytic polysaccharide monooxygenase from family AA9 was steadily expressed throughout growth on both substrates. P450 sequences from clans CPY52 and CYP64 accounted for 50% or more of the most highly expressed P450s, which were also the P450 clans that were expanded in the P. carnosa genome relative to other white-rot fungi. CONCLUSIONS: The inclusion of five growth points and two wood substrates was important to revealing differences in the expression profiles of specific sequences within large glycoside hydrolase families (e.g., GH5 and GH16), and permitted co-expression analyses that identified new targets for study, including non-catalytic proteins and proteins with unknown function.
Abstract With the emerging demands of new communication services, the contradiction between capacity demand and spectrum shortage of railway communication systems becomes more severe. How to provide broadband communication services has become the key goal of future smart high-speed railway (HSR) systems. Millimeter wave (mm-wave) frequency band has abundant spectrum resources and can provide communication services with large bandwidth. However, due to the high-speed of the train as well as the complexity and dynamics of environments, the communication link may be blocked randomly for a short time and will also lead to frequent handovers. In this paper, we adopt the promising intelligent reflecting surface (IRS) technology for a mm-wave HSR communication system. In order to improve system capacity, IRS is deployed to improve reflection transmission links, and optimization algorithms are designed for transceiver beamforming and IRS phase shift. In addition, given the specificity of the HSR scenario, we also formulate the average system ergodic capacity maximization problem and obtain upper bound on the average system ergodic capacity with statistical channel state information (CSI). Through extensive simulations, we verify that the proposed scheme performs significantly better than the other two baseline schemes in terms of average system throughput and average system ergodic capacity.
Abstract Background: We evaluated whether early measurement of soluble urokinase plasminogen activator receptor (suPAR) could predict future risk of postoperative complications in initially asymptomatic patients with mild-moderate aortic stenosis (AS) undergoing aortic valve replacement (AVR) surgery. Methods: aseline plasma suPAR levels were available in 411 patients who underwent AVR surgery during follow-up in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study. Cox analyses were used to evaluate suPAR in relation to all-cause mortality and the composite endpoint of postoperative complications (all-cause mortality, congestive heart failure, stroke and renal impairment) occurring in the 30-day postoperative period. Results: Patients with initially higher levels of suPAR were at increased risk of postoperative mortality with a HR of 3.5 (95% CI 1.4 to 9.0, P=0.008) and postoperative complications with a HR of 2.7 (95% CI 1.5 to 5.1, P=0.002), per doubling in suPAR. After adjusting for the European System for Cardiac Operative Risk Evaluation or Society of Thoracic Surgeons risk score, suPAR remained associated with postoperative mortality with a HR 3.2 (95% CI 1.2 to 8.6, P=0.025) and 2.7 (95% CI 1.0 to 7.8, P=0.061); and postoperative complications with a HR of 2.5 (95% CI 1.3 to 5.0, P=0.007) and 2.4 (95% CI 1.2 to 4.8, P=0.011), respectively. Conclusions: Higher baseline suPAR levels are associated with an increased risk for postoperative complications and mortality in patients with mild-moderate, asymptomatic AS undergoing later AVR surgery. Further validation in other subsets of AS individuals are warranted.
Abstract We report the observation of new properties of primary iron (Fe) cosmic rays in the rigidity range 2.65 GV to 3.0 TV with 0.62×106 iron nuclei collected by the Alpha Magnetic Spectrometer experiment on the International Space Station. Above 80.5 GV the rigidity dependence of the cosmic ray Fe flux is identical to the rigidity dependence of the primary cosmic ray He, C, and O fluxes, with the Fe/O flux ratio being constant at 0.155±0.006. This shows that unexpectedly Fe and He, C, and O belong to the same class of primary cosmic rays which is different from the primary cosmic rays Ne, Mg, and Si class.
Abstract During disturbed geomagnetic conditions, the energetic particles in the inner magnetosphere are known to undergo precipitation loss due to interaction with various plasma waves. This study, investigates the energetic particle precipitation events statistically using coordinate observations from the ground riometer network and the inner-magnetospheric satellite mission, Arase. We have compared cosmic noise absorption (CNA) data obtained from the Finnish ground riometer network located in the auroral/sub-auroral latitudes with the comprehensive data set of omnidirectional electron/proton flux and plasma waves in ELF/VLF frequency range from the Arase satellite during the overpass intervals. The study period includes one and a half years of data between March 2017 and September 2018 covering Arase conjunctions with the riometer stations from all magnetic local time sectors. The relation between the plasma flux/waves observed at the satellite with the riometer absorptions are investigated statistically for CNA (absorption >0.5 dB) and non-CNA (absorption <0.5 dB) cases separately. During CNA events, Arase observed elevated electron flux in the medium energy range (2–100 keV), and plasma wave activity in the whistler-mode frequency range (0.5–3 kHz) of the spectra. Our study provides an estimate of the statistical dependence of the electron flux and plasma wave observations at Arase with the ground reality of actual precipitation.
Abstract Precise knowledge of the charge and rigidity dependence of the secondary cosmic ray fluxes and the secondary-to-primary flux ratios is essential in the understanding of cosmic ray propagation. We report the properties of heavy secondary cosmic ray fluorine F in the rigidity \(R\) range 2.15 GV to 2.9 TV based on 0.29 million events collected by the Alpha Magnetic Spectrometer experiment on the International Space Station. The fluorine spectrum deviates from a single power law above 200 GV. The heavier secondary-to-primary F/Si flux ratio rigidity dependence is distinctly different from the lighter B/O (or B/C) rigidity dependence. In particular, above 10 GV, the \(\frac{F/Si}{B/O}\) ratio can be described by a power law \(R^{δ}\) with \(δ\)=0.052±0.007. This shows that the propagation properties of heavy cosmic rays, from F to Si, are different from those of light cosmic rays, from He to O, and that the secondary cosmic rays have two classes.
Abstract Federated learning (FL) rests on the notion of training a global model in a decentralized manner. Under this setting, mobile devices perform computations on their local data before uploading the required updates to the central aggregator for improving the global model. However, a key challenge is to maintain communication efficiency (i.e., the number of communications per iteration) when participating clients implement uncoordinated computation strategy during aggregation of model parameters. We formulate a utility maximization problem to tackle this difficulty, and propose a novel crowdsourcing framework, involving a number of participating clients with local training data to leverage FL. We show the incentive-based interaction between the crowdsourcing platform and the participating client’s independent strategies for training a global learning model, where each side maximizes its own benefit. We formulate a two-stage Stackelberg game to analyze such scenario and find the game’s equilibria. Further, we illustrate the efficacy of our proposed framework with simulation results. Results show that the proposed mechanism outperforms the heuristic approach with up to 22% gain in the offered reward to attain a level of target accuracy.
Abstract Federated learning (FL) rests on the notion of training a global model in a decentralized manner. Under this setting, mobile devices perform computations on their local data before uploading the required updates to improve the global model. However, when the participating clients implement an uncoordinated computation strategy, the difficulty is to handle the communication efficiency (i.e., the number of communications per iteration) while exchanging the model parameters during aggregation. Therefore, a key challenge in FL is how users participate to build a high-quality global model with communication efficiency. We tackle this issue by formulating a utility maximization problem, and propose a novel crowdsourcing framework to leverage FL that considers the communication efficiency during parameters exchange. First, we show an incentive-based interaction between the crowdsourcing platform and the participating client’s independent strategies for training a global learning model, where each side maximizes its own benefit. We formulate a two-stage Stackelberg game to analyze such scenario and find the game’s equilibria. Second, we formalize an admission control scheme for participating clients to ensure a level of local accuracy. Simulated results demonstrate the efficacy of our proposed solution with up to 22% gain in the offered reward.
Abstract Background and purpose: Protein tyrosine phosphatase receptor type Q (PTPRQ) was extracted from the cerebrospinal fluid (CSF) of patients with probable idiopathic normal‐pressure hydrocephalus (iNPH) by proteome analysis. We aimed to assess the feasibility of using CSF PTPRQ concentrations for the additional diagnostic criterion of iNPH in Japanese and Finnish populations. Methods: We compared PTPRQ concentrations among patients with probable iNPH and neurologically healthy individuals (normal control [NC] group), patients with normal‐pressure hydrocephalus (NPH) of acquired and congenital/developmental aetiologies, patients with Alzheimer’s disease and patients with Parkinson’s disease in a Japanese analysis cohort. A corresponding iNPH group and NC group in a Finnish cohort was used for validation. Patients in the Finnish cohort who underwent biopsy were classified into two groups based on amyloid and/or tau deposition. We measured PTPRQ expression levels in autopsied brain specimens of iNPH patients and the NC group. Results: Cerebrospinal fluid PTPRQ concentrations in the patients with NPH of idiopathic, acquired and congenital/developmental aetiologies were significantly higher than those in the NC group and those with Parkinson’s disease, but iNPH showed no significant differences when compared with those in the Alzheimer’s disease group. For the patients with iNPH, the area under the receiver‐operating characteristic curve was 0.860 in the Japanese iNPH and 0.849 in the Finnish iNPH cohorts. Immunostaining and in situ hybridization revealed PTPRQ expression in the ependymal cells and choroid plexus. It is highly possible that the elevated PTPRQ levels in the CSF are related to ependymal dysfunction from ventricular expansion. Conclusions: Cerebrospinal fluid PTPRQ levels indicated the validity of this assay for auxiliary diagnosis of adult chronic hydrocephalus.
Abstract In the field of Arctic health, “resilience” is a term and concept used to describe capacity to recover from difficulties. While the term is widely used in Arctic policy contexts, there is debate at the community level on whether “resilience” is an appropriate term to describe the human dimensions of health and wellness in the Arctic. Further, research methods used to investigate resilience have largely been limited to Western science research methodologies, which emphasize empirical quantitative studies and may not mirror the perspective of the Arctic communities under study. To explore conceptions of resilience in Arctic communities, a Sharing Circle was facilitated at the International Congress on Circumpolar Health in 2018. With participants engaging from seven of the eight Arctic countries, participants shared critiques of the term “resilience,” and their perspectives on key components of thriving communities. Upon reflection, this use of a Sharing Circle suggests that it may be a useful tool for deeper investigations into health-related issues affecting Arctic Peoples. The Sharing Circle may serve as a meaningful methodology for engaging communities using resonant research strategies to decolonize concepts of resilience and highlight new dimensions for promoting thriving communities in Arctic populations.
Abstract Precision measurements by the Alpha Magnetic Spectrometer (AMS) on the International Space Station of 3He and 4He fluxes are presented. The measurements are based on 100 million 4He nuclei in the rigidity range from 2.1 to 21 GV and 18 million 3He from 1.9 to 15 GV collected from May 2011 to November 2017. We observed that the 3He and 4He fluxes exhibit nearly identical variations with time. The relative magnitude of the variations decreases with increasing rigidity. The rigidity dependence of the 3He/4He flux ratio is measured for the first time. Below 4 GV, the 3He/4He flux ratio was found to have a significant long-term time dependence. Above 4 GV, the 3He/4He flux ratio was found to be time independent, and its rigidity dependence is well described by a single power law ∝RΔ with Δ=−0.294±0.004. Unexpectedly, this value is in agreement with the B/O and B/C spectral indices at high energies.
Abstract Chorus waves, among the most intense electromagnetic emissions in the Earth’s magnetosphere, magnetized planets, and laboratory plasmas, play an important role in the acceleration and loss of energetic electrons in the plasma universe through resonant interactions with electrons. However, the spatial evolution of the electron resonant interactions with electromagnetic waves remains poorly understood owing to imaging difficulties. Here we provide a compelling visualization of chorus element wave–particle interactions in the Earth’s magnetosphere. Through in-situ measurements of chorus waveforms with the Arase satellite and transient auroral flashes from electron precipitation events as detected by 100-Hz video sampling from the ground, Earth’s aurora becomes a display for the resonant interactions. Our observations capture an asymmetric spatial development, correlated strongly with the amplitude variation of discrete chorus elements. This finding is not theoretically predicted but helps in understanding the rapid scattering processes of energetic electrons near the Earth and other magnetized planets.