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The Anglova scenario is designed to support experimentation with tactical networking environments and provides node mobility and network connectivity for a realistic battalion-sized military operation consisting of three vignettes, including the deployment of armored vehicles, surveillance of the maritime domain and an urban operation with a naval component. Altogether, the scenario includes 283 nodes and lasts over four hours with detailed mobility and pathloss data for each node. Also included with the scenario are radio models for the different radios that would be part of a heterogeneous network. The scenario has been developed by the NATO IST-124 Research Task Group and released into the public domain in order to facilitate experimentation with networking protocols and algorithms by the community at large. While primarily designed for the Extendable Mobile Ad-hoc Network Emulator (EMANE), the scenario can also be adapted to other experimentation environments.
Abstract In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.