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For the offshore energy industry, virtual environment technology can enhance conventional training by teaching basic offshore safety protocols such as onboard familiarization and emergency evacuation. Virtual environments have the added benefit of being used to investigate the impact of different training approaches on competence. This pilot study uses decision tree modeling to examine the efficacy of two pedagogical approaches, simulation-based mastery learning (SBML) and lecture-based training (LBT), in a virtual environment. Decision trees are an inductive reasoning approach that can be used to identify learners' egress strategies in offshore emergencies after training. The efficacy of the virtual training is evaluated in three ways: 1) analyzing participants' performance scores in test scenarios; 2) comparing the decision tree depiction of participant's understanding of emergency egress to the intended learning objectives; and 3) comparing the decision strategies developed under a different pedagogical approach. A comparison of the resulting decision trees from the SBML training with trees generated from the LBT showed that the different training methods influenced the participants' egress strategies. The SBML approach resulted in concise decision trees and better route selection strategies when compared to the LBT training. This pilot study demonstrates the diagnostic capabilities of decision trees as training assessment tools and recommends integrating decision trees into virtual training to better support the learning needs of individuals and deliver adaptive training scenarios.
Abstract Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Abstract In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.