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As part of a ‘fitness check’ evaluation of the Common Agricultural Policy (CAP), completed in autumn 2017, we conducted an in depth literature review to evaluate both direct and indirect effects of the CAP on biodiversity (BD) and ecosystem services (ESS). Beyond instruments that are designated towards the protection of BD and ESS, such as agri-environment(-climate) schemes (AECM), greening, and cross compliance (CC), we considered and evaluated non-designated instruments such as Direct Payments, that likely have indirect effects on BD and ESS by affecting land-use changes, farm structure and management. Although literature suggests that AECM can be locally effective (1), their effectiveness at the EU level remains limited due to a restricted budget and extent, low uptake and acceptance by farmers, lack of spatial design, and poor implementation in many cases. Greening measures are both ineffective and cost-inefficient since most farmers are either exempt or can comply with the greening requirements without any action (2). Additionally, administrative requirements bias farmers toward choosing the simplest and least effective measures (3) and management requirements and spatial design are lacking. With respect to supporting farming systems that can be considered as sustainable, our review indicates that the CAP offers adequate support to promote organic farming, but much greater support is given to unsustainable farming systems. Moreover, the protection of High Nature Value farming systems is scarce and inadequate. Concerning ESS, current measures (AECM, CC) are somewhat effective with respect to soil protection and water quality but the performance of the CAP is very low with regard to climate issues by failing to address the most important sources of greenhouse-gas emissions, namely livestock production and nitrogen fertilization. Overall, the CAP’s design and implementation poorly takes up existing knowledge and experience with respect to necessary interventions and best indicators, and its various instruments operate with little coherence (e.g. AECM and organic farming) or even in conflict (e.g. AECM and greening). Moreover, the CAP only marginally addresses the EU's global ecological footprint and its contribution to land-use changes outside of Europe. Thus, the global efficiency and effectiveness of the CAP in terms of BD and ESS remains weak. Our literature review indicates the availability of a wealth of evidence to inform current and future policy design processes. Integration of all available knowledge, in collaboration with the scientific community, will be essential for achieving higher effectiveness, efficiency, and coherence within instruments and among the CAP and the EU’s biodiversity strategy. A much more inclusive, transparent and evidence-based process will be necessary if the European Commission wishes to address the concerns over the CAP’s performance with respect to public goods.
Tässä artikkelissa tarkastellaan työssä hankitun osaamisen opinnollistamista ja työympäristössä tapahtuvan oppimisen merkityksellisyyttä. Pilottihanke osoitti, että opiskelun toteuduttua kiinteässä yhteydessä työelämän kanssa työ näyttäytyi teoriaa ja käytäntöä yhdistävänä kontekstina. Asetelma mahdollisti jopa molemminpuolisen oppimisen. Opinnollistaminen mahdollistaakin koulutuksen ja työelämän rajapinnan tarkastelua oppimisyhteisönä, jossa parhaimmillaan toteutuu koko työyhteisön osaamisen kehittymistä.
Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β cell autoimmunity and type 1 diabetes. We investigated how CVB affects human β cells and anti-CVB T cell responses. β cells were efficiently infected by CVB in vitro, down-regulated human leukocyte antigen (HLA) class I, and presented few, selected HLA-bound viral peptides. Circulating CD8+ T cells from CVB–seropositive individuals recognized a fraction of these peptides; only another subfraction was targeted by effector/memory T cells that expressed exhaustion marker PD-1. T cells recognizing a CVB epitope cross-reacted with β cell antigen GAD. Infected β cells, which formed filopodia to propagate infection, were more efficiently killed by CVB than by CVB-reactive T cells. Our in vitro and ex vivo data highlight limited CD8+ T cell responses to CVB, supporting the rationale for CVB vaccination trials for type 1 diabetes prevention. CD8+ T cells recognizing structural and nonstructural CVB epitopes provide biomarkers to differentially follow response to infection and vaccination.