This practical based guide’s original purpose is to provide a comprehensive, understandable guideline for nursing homes’ workers and students in English, on the topic of MRSA prevention and control. Author searches related information from mainly internet, the used search engines are: the school library masto-finna, PubMed, Medic, ScienceDirect. Later on, more information was gathered through websites: European Centre for Disease Prevention and Control, Eurosurveillance, the journal of hospital infection, Nice clinical guideline centre, WHO, and THL. Most of current MRSA prevention guidelines and qualified studies are based on hospitals, only a few of guidelines and researches are for long term healthcare facilities, and no qualified, reliable, practical guideline was found for nursing home. Thus, on the basis of most popular and reliable guidelines for long term care facilities (published by WHO, CDC), author combines nursing home practice (from own work experience and communication with other workers) and latest nursing home articles/studies, proposed a nursing guide for nursing homes with MRSA residents, inferred a few practical problems on the basis of facts of nursing homes, assumed possible reasons, made an short brochure, to be more simple and applicable.